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    CARM1 coactivator associated arginine methyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 10498, updated on 3-Dec-2024

    Summary

    Official Symbol
    CARM1provided by HGNC
    Official Full Name
    coactivator associated arginine methyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:23393
    See related
    Ensembl:ENSG00000142453 MIM:603934; AllianceGenome:HGNC:23393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRMT4
    Summary
    This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CARM1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10871553..10923075)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10998565..11050086)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10982229..11033751)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10945386-10946023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10946661-10947297 Neighboring gene chromosome 19 open reading frame 38 Neighboring gene HIKESHI pseudogene 2 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10973529-10974377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13997 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10984976-10985476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10985477-10985977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13999 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10989664-10990506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10991348-10992190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10992191-10993032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993033-10993874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993875-10994715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11004683-11005484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11009921-11010538 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11015702-11015889 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11031708-11031887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11037946-11038648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11038649-11039349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10095 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11046750-11047081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:11048011-11048510 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14001 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11087822-11088514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11120526-11121026 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with coactivator-associated arginine methyltransferase 1 (CARM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables histone H2AQ104 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K37 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R17 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3R17 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3R2 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3R2 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3R2 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3R26 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R8 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K12 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4R3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
     
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
     
    enables protein methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-arginine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein-arginine omega-N asymmetric methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of intracellular estrogen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in replication fork reversal IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-arginine methyltransferase CARM1
    Names
    protein arginine N-methyltransferase 4
    NP_001357017.1
    NP_001357018.1
    NP_954592.1
    XP_011525940.1
    XP_047294014.1
    XP_054175514.1
    XP_054175515.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370088.1NP_001357017.1  histone-arginine methyltransferase CARM1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC007565, AC011442
      Consensus CDS
      CCDS92516.1
      UniProtKB/TrEMBL
      A0AA34QVH5
      Related
      ENSP00000340934.3, ENST00000344150.8
      Conserved Domains (3) summary
      cd02440
      Location:188283
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      COG0500
      Location:184394
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam11531
      Location:34138
      CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
    2. NM_001370089.1NP_001357018.1  histone-arginine methyltransferase CARM1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007565, AC011442
      UniProtKB/TrEMBL
      A0AA34QVH5
      Conserved Domains (3) summary
      cd02440
      Location:153248
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      COG0500
      Location:149359
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17171
      Location:33103
      PH-like; Pleckstrin homology-like domain
    3. NM_199141.2NP_954592.1  histone-arginine methyltransferase CARM1 isoform 1

      See identical proteins and their annotated locations for NP_954592.1

      Status: VALIDATED

      Source sequence(s)
      AC007565, AC011442
      Consensus CDS
      CCDS12250.1
      UniProtKB/Swiss-Prot
      A6NN38, Q86X55
      UniProtKB/TrEMBL
      A0AA34QVH5
      Related
      ENSP00000325690.4, ENST00000327064.9
      Conserved Domains (3) summary
      pfam05185
      Location:172435
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam11531
      Location:34138
      CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
      pfam12847
      Location:184283
      Methyltransf_18; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10871553..10923075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438058.1XP_047294014.1  histone-arginine methyltransferase CARM1 isoform X1

      UniProtKB/TrEMBL
      A0AA34QVH5
    2. XM_011527638.3XP_011525940.1  histone-arginine methyltransferase CARM1 isoform X2

      See identical proteins and their annotated locations for XP_011525940.1

      Conserved Domains (2) summary
      pfam05185
      Location:11274
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam12847
      Location:23122
      Methyltransf_18; Methyltransferase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10998565..11050086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319539.1XP_054175514.1  histone-arginine methyltransferase CARM1 isoform X1

      UniProtKB/TrEMBL
      A0AA34QVH5
    2. XM_054319540.1XP_054175515.1  histone-arginine methyltransferase CARM1 isoform X2