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    OBP2A odorant binding protein 2A [ Homo sapiens (human) ]

    Gene ID: 29991, updated on 27-Nov-2024

    Summary

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    Official Symbol
    OBP2Aprovided by HGNC
    Official Full Name
    odorant binding protein 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:23380
    See related
    Ensembl:ENSG00000122136 MIM:164320; AllianceGenome:HGNC:23380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBP; LCN13; OBP2C; OBPIIa; hOBPIIa
    Summary
    This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 2.5), skin (RPKM 0.2) and 1 other tissue See more
    Orthologs
    all
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    Genomic context

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    See OBP2A in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135546126..135549969)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147774075..147777763)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138437972..138441815)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928525 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:138396029-138396183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138397212-138398185 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene NANOG hESC enhancer GRCh37_chr9:138403278-138403841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138406747-138407428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138408918-138409418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138409419-138409919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138416151-138417034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:138418857-138419510 Neighboring gene lipocalin 1 Neighboring gene uncharacterized LOC107987040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138457239-138457870 Neighboring gene progestagen associated endometrial protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor-derived OBP2A promotes prostate cancer castration resistance. Jeong JH, et al. J Exp Med, 2023 Mar 6. PMID 36547668, Free PMC Article
    2. A polymorphism in the human gene encoding OBPIIa affects the perceived intensity of smelled odors. Sollai G, et al. Behav Brain Res, 2022 Jun 3. PMID 35341882
    3. Mammalian odorant binding proteins. Tegoni M, et al. Biochim Biophys Acta, 2000 Oct 18. PMID 11058764
    4. Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene. Sollai G, et al. Nutrients, 2021 Feb 22. PMID 33671721, Free PMC Article
    5. Effect of the rs2890498 polymorphism of the OBPIIa gene on the human ability to smell single molecules. Melis M, et al. Behav Brain Res, 2021 Mar 26. PMID 33422593

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation.
      Title: Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation.
    2. Tumor-derived OBP2A promotes prostate cancer castration resistance.
      Title: Tumor-derived OBP2A promotes prostate cancer castration resistance.
    3. A polymorphism in the human gene encoding OBPIIa affects the perceived intensity of smelled odors.
      Title: A polymorphism in the human gene encoding OBPIIa affects the perceived intensity of smelled odors.
    4. Effect of the rs2890498 polymorphism of the OBPIIa gene on the human ability to smell single molecules.
      Title: Effect of the rs2890498 polymorphism of the OBPIIa gene on the human ability to smell single molecules.
    5. Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes.
      Title: Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes.
    6. Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene.
      Title: Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene.
    7. Importantly, OBPIIa gene polymorphism showed an effect on Parkinson's disease-related olfactory deficits only in women.
      Title: Odor Identification Performance in Idiopathic Parkinson's Disease Is Associated With Gender and the Genetic Variability of the Olfactory Binding Protein.
    8. Association between the rs2590498 polymorphism of Odorant Binding Protein (OBPIIa) gene and olfactory performance in healthy subjects.
      Title: Association between the rs2590498 polymorphism of Odorant Binding Protein (OBPIIa) gene and olfactory performance in healthy subjects.
    9. This study demonstrated that the OBPIIa is associated with bitter sensitivity in human.
      Title: Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people.
    10. Studied the crystallographic structure of human odorant-binding protein, OBPIIa at 2.6 A resolution.
      Title: Crystal structure of the human odorant binding protein, OBPIIa.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables odorant binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables odorant binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of chemical stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    odorant-binding protein 2a
    Names
    odorant-binding protein IIa
    putative odorant-binding protein 2c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029693.1 RefSeqGene

      Range
      4988..8831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001293189.2 → NP_001280118.1  odorant-binding protein 2a isoform gamma precursor

      Status: REVIEWED

      Source sequence(s)
      AI219510, AJ251024, AL161452, BC143803
      Consensus CDS
      CCDS78455.1
      UniProtKB/TrEMBL
      A0A087WXL2, Q5T8A5
      Related
      ENSP00000342097.3, ENST00000340780.7
      Conserved Domains (1) summary
      pfam00061
      Location:26 → 130
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001293193.2 → NP_001280122.1  odorant-binding protein 2a isoform delta precursor

      Status: REVIEWED

      Source sequence(s)
      AI219510, AJ251023, AL161452, BC069563
      Consensus CDS
      CCDS78456.1
      UniProtKB/TrEMBL
      Q5T8A4
      Related
      ENSP00000340950.4, ENST00000342114.8
      Conserved Domains (1) summary
      pfam00061
      Location:107 → 141
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_001412135.1 → NP_001399064.1  odorant-binding protein 2a isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      CP068269
      UniProtKB/TrEMBL
      B7ZLH4

    4. NM_014582.3 → NP_055397.1  odorant-binding protein 2a isoform alpha precursor

      Status: REVIEWED

      Source sequence(s)
      AI219510, AJ251021, AL161452
      Consensus CDS
      CCDS6992.1
      UniProtKB/Swiss-Prot
      Q5T8A3, Q9NY50, Q9NY53, Q9NY54, Q9NY55, Q9NY56
      UniProtKB/TrEMBL
      Q2PAD7
      Related
      ENSP00000360841.1, ENST00000371776.6
      Conserved Domains (1) summary
      pfam00061
      Location:26 → 164
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RNA

    1. NR_120603.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI219510, AJ251022, AJ251023, AL161452
      Related
      ENST00000471886.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      135546126..135549969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      147774075..147777763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NY56.1 GenPept UniProtKB/Swiss-Prot:Q9NY56

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