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    Lmod3 leiomodin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500267, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Lmod3provided by RGD
    Official Full Name
    leiomodin 3provided by RGD
    Primary source
    RGD:1564924
    See related
    EnsemblRapid:ENSRNOG00000032443 AllianceGenome:RGD:1564924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564924
    Summary
    Predicted to enable actin monomer binding activity and tropomyosin binding activity. Predicted to be involved in several processes, including actin nucleation; muscle cell development; and positive regulation of skeletal muscle fiber development. Predicted to be located in M band. Predicted to be active in striated muscle thin filament. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 582.1) and Heart (RPKM 85.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmod3 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (131400643..131415411, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129843964..129858684, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129604378..129619136, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102348 Neighboring gene ADP-ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene ubiquitin-like modifier activating enzyme 3 Neighboring gene FERM domain containing 4B Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy. Tian L, et al. Dis Model Mech, 2015 Jun. PMID 26035871, Free PMC Article
    2. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. Yuen M, et al. J Clin Invest, 2014 Nov. PMID 25250574, Free PMC Article
    3. Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3. Cenik BK, et al. J Clin Invest, 2015 Apr. PMID 25774500, Free PMC Article
    4. KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. Garg A, et al. J Clin Invest, 2014 Aug. PMID 24960163, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle thin filament assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leiomodin 3; leiomodin-3
    Names
    leiomodin 3 (fetal)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431837.1 → NP_001418766.1  leiomodin 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    2. NM_001431838.1 → NP_001418767.1  leiomodin 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    3. NM_001431839.1 → NP_001418768.1  leiomodin 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      131400643..131415411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236972.5 → XP_006237034.1  leiomodin-3

      UniProtKB/TrEMBL
      D4A871
      Related
      ENSRNOP00000042274.5, ENSRNOT00000047453.7
      Conserved Domains (2) summary
      cd00116
      Location:267 → 361
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:16 → 125
      Tropomodulin; Tropomodulin

    2. XM_006236973.5 → XP_006237035.1  leiomodin-3

      UniProtKB/TrEMBL
      D4A871
      Conserved Domains (2) summary
      cd00116
      Location:267 → 361
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:16 → 125
      Tropomodulin; Tropomodulin
    Nucleotide Protein Strain
    Heading Accession and Version

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