ATF1 activating transcription factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATF1provided by HGNC
Official Full Name: activating transcription factor 1provided by HGNC
Primary source: HGNC:HGNC:783
See related: Ensembl:ENSG00000123268 MIM:123803; AllianceGenome:HGNC:783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TREB36; EWS-ATF1; FUS/ATF-1
Summary: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Expression: Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (50763459..50821162)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (50726620..50784323)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (51157242..51214945)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory Response and Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Regulating NF-kappaB Pathway.
Title: Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory Response and Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Regulating NF-κB Pathway.
BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin.
Title: BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin.
ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression.
Title: ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression.
Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis.
Title: Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis.
Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma.
Title: Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma.
ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction.
Title: ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction.
Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer.
Title: Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer.
Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma.
Title: Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma.
Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients.
Title: Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients.
Colorectal cancer risk variant rs7017386 modulates two oncogenic lncRNAs expression via ATF1-mediated long-range chromatin loop.
Title: Colorectal cancer risk variant rs7017386 modulates two oncogenic lncRNAs expression via ATF1-mediated long-range chromatin loop.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr activation of activating protein 1-regulated promoters is linked to Vpr regulation of IL-12, CD44, Toll-like receptor 4, indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1	PubMed
	vpr	HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on activating protein 1-regulated simple promoters	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44890 (e-PCR)
- UniSTS:8818

RH102820 (e-PCR)
- UniSTS:97154

G32549 (e-PCR)
- UniSTS:117133

ATF1_4332 (e-PCR)
- UniSTS:462752

A009H30 (e-PCR)
- UniSTS:39118

RH71282 (e-PCR)
- UniSTS:16866

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to cobalt ion	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of ATF1-ATF4 transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATF4-CREB1 transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-1

Names: cAMP-dependent transcription factor ATF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027673.1 RefSeqGene

Range

5096..62157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001412960.1 → NP_001399889.1 cyclic AMP-dependent transcription factor ATF-1 isoform a

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/TrEMBL

B2R8K4
NM_001412961.1 → NP_001399890.1 cyclic AMP-dependent transcription factor ATF-1 isoform b

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/TrEMBL

B2R8K4
NM_001412962.1 → NP_001399891.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412963.1 → NP_001399892.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412964.1 → NP_001399893.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412965.1 → NP_001399894.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412966.1 → NP_001399895.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412967.1 → NP_001399896.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

Status: REVIEWED

Source sequence(s)

AC013244

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
NM_001412968.1 → NP_001399897.1 cyclic AMP-dependent transcription factor ATF-1 isoform d

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412969.1 → NP_001399898.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412970.1 → NP_001399899.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412971.1 → NP_001399900.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412972.1 → NP_001399901.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412973.1 → NP_001399902.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412974.1 → NP_001399903.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412975.1 → NP_001399904.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412976.1 → NP_001399905.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412977.1 → NP_001399906.1 cyclic AMP-dependent transcription factor ATF-1 isoform e

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412978.1 → NP_001399907.1 cyclic AMP-dependent transcription factor ATF-1 isoform f

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412979.1 → NP_001399908.1 cyclic AMP-dependent transcription factor ATF-1 isoform f

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412980.1 → NP_001399909.1 cyclic AMP-dependent transcription factor ATF-1 isoform f

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412981.1 → NP_001399910.1 cyclic AMP-dependent transcription factor ATF-1 isoform f

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412982.1 → NP_001399911.1 cyclic AMP-dependent transcription factor ATF-1 isoform f

Status: REVIEWED

Source sequence(s)

AC013244
NM_001412983.1 → NP_001399912.1 cyclic AMP-dependent transcription factor ATF-1 isoform g

Status: REVIEWED

Source sequence(s)

AC013244
NM_005171.5 → NP_005162.1 cyclic AMP-dependent transcription factor ATF-1 isoform c

See identical proteins and their annotated locations for NP_005162.1

Status: REVIEWED

Source sequence(s)

AC013244, DA468394

Consensus CDS

CCDS8803.1

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4

Related

ENSP00000262053.3, ENST00000262053.8

Conserved Domains (2) summary

cd14690
Location:215 → 269

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:48 → 82

pKID; pKID domain

RNA

NR_182081.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC013244

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

50763459..50821162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011538386.3 → XP_011536688.1 cyclic AMP-dependent transcription factor ATF-1 isoform X2

See identical proteins and their annotated locations for XP_011536688.1

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4

Conserved Domains (2) summary

cd14690
Location:215 → 269

bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

pfam02173
Location:48 → 82

pKID; pKID domain
XM_017019331.2 → XP_016874820.1 cyclic AMP-dependent transcription factor ATF-1 isoform X1

UniProtKB/TrEMBL

B2R8K4
XM_047428878.1 → XP_047284834.1 cyclic AMP-dependent transcription factor ATF-1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

50726620..50784323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372108.1 → XP_054228083.1 cyclic AMP-dependent transcription factor ATF-1 isoform X2

UniProtKB/Swiss-Prot

B4DRF9, P18846, P25168, Q9H4A8

UniProtKB/TrEMBL

B2R8K4
XM_054372107.1 → XP_054228082.1 cyclic AMP-dependent transcription factor ATF-1 isoform X1

UniProtKB/TrEMBL

B2R8K4
XM_054372109.1 → XP_054228084.1 cyclic AMP-dependent transcription factor ATF-1 isoform X3