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    CDCA2 cell division cycle associated 2 [ Homo sapiens (human) ]

    Gene ID: 157313, updated on 14-Nov-2024

    Summary

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    Official Symbol
    CDCA2provided by HGNC
    Official Full Name
    cell division cycle associated 2provided by HGNC
    Primary source
    HGNC:HGNC:14623
    See related
    Ensembl:ENSG00000184661 MIM:618785; AllianceGenome:HGNC:14623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPP1R81; Repo-Man
    Summary
    This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDCA2 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (25458931..25507917)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (25734151..25783086)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25316447..25365433)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27125 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:25336688-25337887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:25338615-25339116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:25339117-25339616 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:25348932-25349432 Neighboring gene Sharpr-MPRA regulatory region 1118 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:25457409-25458332 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:25472096-25472597 Neighboring gene uncharacterized LOC107986933 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25517514-25518200 Neighboring gene uncharacterized LOC105379333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:25532846-25533449 Neighboring gene NANOG hESC enhancer GRCh37_chr8:25537050-25537623 Neighboring gene uncharacterized LOC105379332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Role of CDCA2 in tumor genesis, prognosis and future treatments. Lin X, et al. Eur J Cancer, 2024 Nov. PMID 39288736
    2. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. Uchida F, et al. PLoS One, 2013. PMID 23418564, Free PMC Article
    3. Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase). Prévost M, et al. Mol Cell Proteomics, 2013 May. PMID 23362328, Free PMC Article
    4. Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation. Huguet F, et al. Open Biol, 2022 Apr. PMID 35414260, Free PMC Article
    5. Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Vagnarelli P, et al. Nucleus, 2012 Mar 1. PMID 22555598, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of CDCA2 in tumor genesis, prognosis and future treatments.
      Title: The Role of CDCA2 in tumor genesis, prognosis and future treatments.
    2. A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.
      Title: A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade glioma.
    3. CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
      Title: CDCA2 promotes melanoma progression by inhibiting ubiquitin-mediated degradation of Aurora kinase A.
    4. PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma.
      Title: PPP1R81 correlates with the survival and cell proliferation in lower-grade glioma.
    5. Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner.
      Title: Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner.
    6. CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
      Title: CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
    7. Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation.
      Title: Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation.
    8. CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
      Title: CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.
    9. RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
      Title: RepoMan stimulates the chromosome-dependent pathway of microtubule assembly.
    10. CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
      Title: CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25804, MGC129906, MGC129907

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 2
    Names
    protein phosphatase 1, regulatory subunit 81
    recruits PP1 onto mitotic chromatin at anaphase protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317906.1 → NP_001304835.1  cell division cycle-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) retains a 5' intron resulting in a distinct 5' UTR and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to variant 1.
      Source sequence(s)
      AA678348, AI022757, AK292505, AL833396, DB093475
      Consensus CDS
      CCDS83266.1
      UniProtKB/TrEMBL
      A8K8Z0, E9PEI0
      Related
      ENSP00000370040.3, ENST00000380665.3
      Conserved Domains (1) summary
      pfam15276
      Location:375 → 433
      PP1_bind; Protein phosphatase 1 binding

    2. NM_001317907.1 → NP_001304836.1  cell division cycle-associated protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA678348, AI022757, AK292505, AK299278, AL833396, DB093475
      UniProtKB/TrEMBL
      B7Z5Q5
      Conserved Domains (1) summary
      pfam15276
      Location:390 → 448
      PP1_bind; Protein phosphatase 1 binding

    3. NM_152562.4 → NP_689775.2  cell division cycle-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_689775.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA678348, AI022757, AK299278, AL833396, BC015691
      Consensus CDS
      CCDS6049.1
      UniProtKB/Swiss-Prot
      Q3SX74, Q4G0W0, Q5RKN0, Q69YH5, Q69YI4, Q6P464, Q8N7C1
      UniProtKB/TrEMBL
      A8K8Z0
      Related
      ENSP00000328228.3, ENST00000330560.8
      Conserved Domains (1) summary
      pfam15276
      Location:390 → 448
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      25458931..25507917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      25734151..25783086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69YH5.2 GenPept UniProtKB/Swiss-Prot:Q69YH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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