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    IL36A interleukin 36 alpha [ Homo sapiens (human) ]

    Gene ID: 27179, updated on 28-Oct-2024

    Summary

    Official Symbol
    IL36Aprovided by HGNC
    Official Full Name
    interleukin 36 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:15562
    See related
    Ensembl:ENSG00000136694 MIM:605509; AllianceGenome:HGNC:15562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
    Summary
    The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward esophagus (RPKM 90.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IL36A in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113005459..113011072)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113431988..113437599)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113763036..113765621)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23 Neighboring gene interleukin 36 gamma Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16409 Neighboring gene POLR2D pseudogene 1 Neighboring gene interleukin 36 beta Neighboring gene Sharpr-MPRA regulatory region 4990 Neighboring gene interleukin 36 receptor antagonist

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129552, MGC129553

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-1 receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-36 alpha
    Names
    FIL1 epsilon
    IL-1 epsilon
    IL-1F6 (FIL-1-epsilon)
    interleukin 1 family, member 6 (epsilon)
    interleukin-1 epsilon
    interleukin-1 family member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014440.3NP_055255.1  interleukin-36 alpha

      See identical proteins and their annotated locations for NP_055255.1

      Status: REVIEWED

      Source sequence(s)
      AC016724, AF201831, AK314149
      Consensus CDS
      CCDS42734.1
      UniProtKB/Swiss-Prot
      B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7
      Related
      ENSP00000259211.6, ENST00000259211.7
      Conserved Domains (1) summary
      cl00094
      Location:15152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      113005459..113011072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510965.2XP_011509267.1  interleukin-36 alpha isoform X1

      See identical proteins and their annotated locations for XP_011509267.1

      UniProtKB/Swiss-Prot
      B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7
      Conserved Domains (1) summary
      cl00094
      Location:15152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. XM_005263639.3XP_005263696.1  interleukin-36 alpha isoform X1

      See identical proteins and their annotated locations for XP_005263696.1

      UniProtKB/Swiss-Prot
      B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7
      Conserved Domains (1) summary
      cl00094
      Location:15152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    3. XM_017003806.2XP_016859295.1  interleukin-36 alpha isoform X1

      UniProtKB/Swiss-Prot
      B2RAD9, Q53SR7, Q5BLR4, Q7RTZ8, Q9UHA7
      Conserved Domains (1) summary
      cl00094
      Location:15152
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      113431988..113437599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341389.1XP_054197364.1  interleukin-36 alpha isoform X1

    2. XM_054341387.1XP_054197362.1  interleukin-36 alpha isoform X1

    3. XM_054341388.1XP_054197363.1  interleukin-36 alpha isoform X1