Yod1 YOD1 deubiquitinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yod1provided by MGI
Official Full Name: YOD1 deubiquitinaseprovided by MGI
Primary source: MGI:MGI:2442596
See related: Ensembl:ENSMUSG00000046404 AllianceGenome:MGI:2442596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hshin7; 6330564D18Rik; 9930028C20Rik
Summary: Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein deubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 8.7), liver E14 (RPKM 3.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130645064..130652093)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130717327..130722073)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3.
Title: YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3.
YOD1 binds to and deubiquitinates neural precursor cell expressed developmentally down-regulated protein 4. YOD1 suppresses NEDD4-induced cell proliferation.
Title: YOD1 Deubiquitinates NEDD4 Involved in the Hippo Signaling Pathway.
findings thus provided novel insights into the regulatory cascade of the cellular antiviral response through YOD1-mediated K63-linked deubiquitination and aggregation of MAVS.
Title: The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination.
YOD1 levels significantly increase in cells and tissues in response to various pathophysiological conditions.
Title: YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity.
Antigen presenting cells (APCs) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8(+) T cells, both in vitro and in vivo.
Title: A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K27-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K29-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K33-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K33-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin thioesterase OTU1

Names: HIV-induced protein-7-like protease; YOD1 OTU deubiquitinating enzyme 1 homologue

NP_848806.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178691.5 → NP_848806.2 ubiquitin thioesterase OTU1

See identical proteins and their annotated locations for NP_848806.2

Status: VALIDATED

Source sequence(s)

AC139231

Consensus CDS

CCDS48351.1

UniProtKB/Swiss-Prot

B2RSW9, Q8BPM9, Q8CB24, Q8CB27

UniProtKB/TrEMBL

A4FTZ0

Related

ENSMUSP00000055318.5, ENSMUST00000049813.6

Conserved Domains (3) summary

COG5539
Location:72 → 342

COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]

cl00155
Location:41 → 84

UBQ; Ubiquitin-like proteins

cl19932
Location:150 → 265

OTU; OTU-like cysteine protease