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    CPXM2 carboxypeptidase X, M14 family member 2 [ Homo sapiens (human) ]

    Gene ID: 119587, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CPXM2provided by HGNC
    Official Full Name
    carboxypeptidase X, M14 family member 2provided by HGNC
    Primary source
    HGNC:HGNC:26977
    See related
    Ensembl:ENSG00000121898 MIM:617348; AllianceGenome:HGNC:26977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPX2; UNQ676
    Summary
    Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in urinary bladder (RPKM 10.5), fat (RPKM 8.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CPXM2 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (123745639..123944104, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124622492..124821277, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125505155..125651323, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125425617-125426155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125426156-125426693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125430545-125431046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443142-125443642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443643-125444143 Neighboring gene G protein-coupled receptor 26 Neighboring gene uncharacterized LOC105378532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125488883-125489382 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125506649-125507630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125520224-125521126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125521127-125522029 Neighboring gene uncharacterized LOC105378533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125541445-125542192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125619193-125619693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125623194-125623935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125625482-125626289 Neighboring gene Sharpr-MPRA regulatory region 15643 Neighboring gene uncharacterized LOC105378534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:125685728-125686927 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125707945-125708625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125710066-125710566 Neighboring gene uncharacterized LOC107984128 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10754 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_10761 and experimental_10770 Neighboring gene YBX2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma. Zhao X, et al. Diagn Pathol, 2019 Oct 24. PMID 31651348, Free PMC Article
    2. Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer. Niu G, et al. Oncol Rep, 2019 Oct. PMID 31364750, Free PMC Article
    3. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
    4. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. Xin X, et al. DNA Cell Biol, 1998 Oct. PMID 9809751
    5. Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease. Chen YC, et al. Sci Rep, 2016 Nov 2. PMID 27805002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
      Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    2. imply an active role for Carboxypeptidase X, M14 family member 2 in promoting tumor aggressiveness via epithelial to mesenchymal transition (EMT) modulation in osteosarcoma
      Title: Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma.
    3. Results imply an active role for CPXM2 in promoting tumor aggressiveness via epithelial to mesenchymal transition (EMT) modulation in GCs.
      Title: Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer.
    4. The Genetic variants located in CPXM2 have the potential to modulate disease course in MS patients and may be used as disease activity biomarkers to identify patients with divergent disease courses.
      Title: Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.
    5. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics.
      Title: Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours in patients with COPD.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive carboxypeptidase-like protein X2
    Names
    4632435C11Rik
    carboxypeptidase Hlo
    carboxypeptidase X (M14 family), member 2
    carboxypeptidase-like protein X2
    cytosolic carboxypeptidase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052814.1 RefSeqGene

      Range
      57288..203456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198148.3 → NP_937791.2  inactive carboxypeptidase-like protein X2 precursor

      See identical proteins and their annotated locations for NP_937791.2

      Status: VALIDATED

      Source sequence(s)
      AC009987, AY358565
      Consensus CDS
      CCDS7637.1
      UniProtKB/Swiss-Prot
      B4E3Q2, Q8N436
      UniProtKB/TrEMBL
      B4E1X6
      Related
      ENSP00000241305.3, ENST00000241305.4
      Conserved Domains (4) summary
      cd03869
      Location:314 → 639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:643 → 718
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:138 → 293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137 → 292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      123745639..123944104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015673.2 → XP_016871162.1  inactive carboxypeptidase-like protein X2 isoform X3

      UniProtKB/TrEMBL
      Q658N0
      Conserved Domains (4) summary
      cd03869
      Location:205 → 530
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:534 → 609
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:29 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:28 → 183
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    2. XM_011539285.3 → XP_011537587.1  inactive carboxypeptidase-like protein X2 isoform X3

      UniProtKB/TrEMBL
      Q658N0
      Conserved Domains (4) summary
      cd03869
      Location:205 → 530
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:534 → 609
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:29 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:28 → 183
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    3. XM_011539286.2 → XP_011537588.1  inactive carboxypeptidase-like protein X2 isoform X4

      UniProtKB/TrEMBL
      B4DU57
      Conserved Domains (4) summary
      cd03869
      Location:87 → 412
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:416 → 491
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:1 → 66
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:1 → 65
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    4. XM_017015674.2 → XP_016871163.1  inactive carboxypeptidase-like protein X2 isoform X5

      UniProtKB/TrEMBL
      B4DU57

    5. XM_011539283.3 → XP_011537585.1  inactive carboxypeptidase-like protein X2 isoform X2

      UniProtKB/TrEMBL
      B4E1X6
      Conserved Domains (4) summary
      cd03869
      Location:314 → 639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      smart00231
      Location:138 → 293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137 → 292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21470
      Location:643 → 674
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    6. XM_005269528.4 → XP_005269585.1  inactive carboxypeptidase-like protein X2 isoform X1

      UniProtKB/TrEMBL
      B4E1X6
      Conserved Domains (4) summary
      cd03869
      Location:314 → 639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:643 → 678
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:138 → 293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137 → 292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      124622492..124821277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364763.1 → XP_054220738.1  inactive carboxypeptidase-like protein X2 isoform X3

      UniProtKB/TrEMBL
      B4DK28, Q658N0

    2. XM_054364764.1 → XP_054220739.1  inactive carboxypeptidase-like protein X2 isoform X3

      UniProtKB/TrEMBL
      B4DK28, Q658N0

    3. XM_054364765.1 → XP_054220740.1  inactive carboxypeptidase-like protein X2 isoform X4

      UniProtKB/TrEMBL
      B4DU57

    4. XM_054364766.1 → XP_054220741.1  inactive carboxypeptidase-like protein X2 isoform X5

      UniProtKB/TrEMBL
      B4DU57

    5. XM_054364762.1 → XP_054220737.1  inactive carboxypeptidase-like protein X2 isoform X2

      UniProtKB/TrEMBL
      B4E1X6

    6. XM_054364761.1 → XP_054220736.1  inactive carboxypeptidase-like protein X2 isoform X1

      UniProtKB/TrEMBL
      B4E1X6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N436.3 GenPept UniProtKB/Swiss-Prot:Q8N436

    Gene LinkOut

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