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    ATP5IF1 ATP synthase inhibitory factor subunit 1 [ Homo sapiens (human) ]

    Gene ID: 93974, updated on 10-Dec-2024

    Summary

    Official Symbol
    ATP5IF1provided by HGNC
    Official Full Name
    ATP synthase inhibitory factor subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:871
    See related
    Ensembl:ENSG00000130770 MIM:614981; AllianceGenome:HGNC:871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IP; ATPI; ATPIP; ATPIF1
    Summary
    Enables several functions, including ATPase binding activity; angiostatin binding activity; and mitochondrial proton-transporting ATP synthase complex binding activity. Involved in several processes, including mitochondrial depolarization; negative regulation of endothelial cell proliferation; and regulation of protein targeting to mitochondrion. Located in cell surface and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 44.4), colon (RPKM 33.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ATP5IF1 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28236124..28238100)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28077959..28079935)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28562635..28564611)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28474708-28475208 Neighboring gene platelet activating factor receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 535 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28559230-28559763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28561534-28562040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28572195-28572694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 593 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28576752-28577625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28585772-28586620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 537 Neighboring gene sestrin 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:28616419-28617413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28640148-28640648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28655585-28656092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28656093-28656600 Neighboring gene mediator complex subunit 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1167, MGC8898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables angiostatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mitochondrial proton-transporting ATP synthase complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ATP-dependent activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitochondrial ATP synthesis coupled proton transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type 2 mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ATP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ATPase inhibitor, mitochondrial
    Names
    ATP synthase F1 subunit epsilon
    ATP synthase inhibitor protein
    ATPase inhibitor protein
    ATPase inhibitory factor 1
    IF(1)
    IF1
    inhibitor of F(1)F(o)-ATPase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016311.5NP_057395.1  ATPase inhibitor, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_057395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BP271519
      Consensus CDS
      CCDS319.1
      UniProtKB/Swiss-Prot
      Q5JXL8, Q6IAQ7, Q9BSL9, Q9UII2
      Related
      ENSP00000335203.5, ENST00000335514.10
      Conserved Domains (1) summary
      pfam04568
      Location:3687
      IATP; Mitochondrial ATPase inhibitor, IATP
    2. NM_178190.3NP_835497.1  ATPase inhibitor, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_835497.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL583540, DB030607
      Consensus CDS
      CCDS320.1
      UniProtKB/TrEMBL
      A0A0B4J230
      Related
      ENSP00000435579.1, ENST00000497986.5
      Conserved Domains (1) summary
      pfam04568
      Location:3660
      IATP; Mitochondrial ATPase inhibitor, IATP
    3. NM_178191.3NP_835498.1  ATPase inhibitor, mitochondrial isoform 3 precursor

      See identical proteins and their annotated locations for NP_835498.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate segment that causes a frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK000934, AL050386, DB030607
      Consensus CDS
      CCDS44096.1
      UniProtKB/TrEMBL
      A0A0B4J230
      Related
      ENSP00000437337.1, ENST00000465645.1
      Conserved Domains (1) summary
      pfam04568
      Location:3660
      IATP; Mitochondrial ATPase inhibitor, IATP

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28236124..28238100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654706.1 Reference GRCh38.p14 PATCHES

      Range
      29768..31744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28077959..28079935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)