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    GOLM1 golgi membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 51280, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GOLM1provided by HGNC
    Official Full Name
    golgi membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:15451
    See related
    Ensembl:ENSG00000135052 MIM:606804; AllianceGenome:HGNC:15451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3
    Summary
    The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GOLM1 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (86026146..86100149, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98176673..98251783, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88641061..88715064, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19991 Neighboring gene N-alpha-acetyltransferase 35, NatC auxiliary subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88650825-88651760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88677599-88678515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88679748-88680248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88680249-88681249 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88693798-88694997 Neighboring gene Sharpr-MPRA regulatory region 3020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:88713914-88714414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19994 Neighboring gene uncharacterized LOC101927623 Neighboring gene allregulin pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:88761003-88762202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88771625-88772258 Neighboring gene Sharpr-MPRA regulatory region 1717 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:88801905-88802559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19995 Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease. Liu L, et al. Sci Rep, 2018 Nov 13. PMID 30425268, Free PMC Article
    2. Diagnostic accuracy of Golgi protein 73 in primary hepatic carcinoma using ELISA: a systematic review and meta-analysis. Cao FF, et al. Clin Lab, 2014. PMID 24779292
    3. GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. Hu L, et al. PLoS One, 2014. PMID 24608522, Free PMC Article
    4. [Serum GP73 were increased in patients with fatty liver disease]. Wei HS, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 2013 Aug. PMID 24579464
    5. GP73, a new marker for diagnosing HBV-ACLF in population with chronic HBV infections. Wei H, et al. Diagn Microbiol Infect Dis, 2014 May. PMID 24560809

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
      Title: Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization.
    2. GP73 facilitates hepatitis B virus replication by repressing the NF-kappaB signaling pathway.
      Title: GP73 facilitates hepatitis B virus replication by repressing the NF-κB signaling pathway.
    3. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
      Title: PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
    4. Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
      Title: Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress.
    5. Novel serum biomarker of Golgi protein 73 for the diagnosis of clinically significant portal hypertension in patients with compensated cirrhosis.
      Title: Novel serum biomarker of Golgi protein 73 for the diagnosis of clinically significant portal hypertension in patients with compensated cirrhosis.
    6. LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918.
      Title: LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918.
    7. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
      Title: GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling.
    8. GOLM1 Promotes Epithelial-Mesenchymal Transition by Activating TGFbeta1/Smad2 Signaling in Prostate Cancer.
      Title: GOLM1 Promotes Epithelial-Mesenchymal Transition by Activating TGFβ1/Smad2 Signaling in Prostate Cancer.
    9. GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3beta/EMT axis.
      Title: GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3β/EMT axis.
    10. Glypican-3, Vascular Endothelial Growth Factor and Golgi Protein-73 for Differentiation between Liver Cirrhosis and Hepatocellular Carcinoma.
      Title: Glypican-3, Vascular Endothelial Growth Factor and Golgi Protein-73 for Differentiation between Liver Cirrhosis and Hepatocellular Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (135)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of golgi membrane protein 1 (GOLM1; C9orf155) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22634, FLJ23608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleus organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi membrane protein 1
    Names
    epididymis luminal protein 46
    golgi membrane protein GP73
    golgi phosphoprotein 2
    golgi protein, 73-kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016548.4 → NP_057632.2  Golgi membrane protein 1

      See identical proteins and their annotated locations for NP_057632.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK027717, AL533767, BC001740
      Consensus CDS
      CCDS35054.1
      UniProtKB/Swiss-Prot
      Q6IAF4, Q8NBJ4, Q9NRB9
      UniProtKB/TrEMBL
      B3KNK9
      Related
      ENSP00000373364.3, ENST00000388712.7
      Conserved Domains (1) summary
      TIGR02169
      Location:41 → 211
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_177937.3 → NP_808800.1  Golgi membrane protein 1

      See identical proteins and their annotated locations for NP_808800.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075557, BC001740, DA116177
      Consensus CDS
      CCDS35054.1
      UniProtKB/Swiss-Prot
      Q6IAF4, Q8NBJ4, Q9NRB9
      UniProtKB/TrEMBL
      B3KNK9
      Related
      ENSP00000373363.3, ENST00000388711.7
      Conserved Domains (1) summary
      TIGR02169
      Location:41 → 211
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      86026146..86100149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      98176673..98251783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099268.1: Suppressed sequence

      Description
      NM_001099268.1: This RefSeq was permanently suppressed because it is primarily intronic sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NBJ4.1 GenPept UniProtKB/Swiss-Prot:Q8NBJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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