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    ADAM15 ADAM metallopeptidase domain 15 [ Homo sapiens (human) ]

    Gene ID: 8751, updated on 9-Dec-2024

    Summary

    Official Symbol
    ADAM15provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 15provided by HGNC
    Primary source
    HGNC:HGNC:193
    See related
    Ensembl:ENSG00000143537 MIM:605548; AllianceGenome:HGNC:193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDC15
    Summary
    The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 41.3), esophagus (RPKM 32.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAM15 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155051316..155062775)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154190701..154202162)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155023792..155035251)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DCST1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1383 Neighboring gene ADAM15-EFNA4 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155029213-155030023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1386 Neighboring gene EFNA4-EFNA3 readthrough Neighboring gene NANOG hESC enhancer GRCh37_chr1:155037167-155037668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155041991-155042503 Neighboring gene ephrin A4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155043017-155043529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155044044-155044556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1391 Neighboring gene ephrin A3 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155058284-155058452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1392

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ADAM metallopeptidase domain 15 (ADAM15) by siRNA inhibits HIV-1 replication in MAGI-CCR5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: DCST1

    Readthrough ADAM15-EFNA4

    Readthrough gene: ADAM15-EFNA4, Included gene: EFNA4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables immunoglobulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to phorbol 13-acetate 12-myristate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in immune response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypobaric hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 15
    Names
    MDC-15
    a disintegrin and metalloproteinase domain 15 (metargidin)
    metalloprotease RGD disintegrin protein
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029667.1 RefSeqGene

      Range
      5031..16490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261464.2NP_001248393.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons in the 3' coding region compared to variant 6. The resulting protein (isoform 7) is shorter compared to isoform 6.
      Source sequence(s)
      AK296925, AL451085, AL691442, BM971880
      Consensus CDS
      CCDS58031.1
      UniProtKB/TrEMBL
      B7Z390
      Related
      ENSP00000432927.1, ENST00000531455.5
      Conserved Domains (5) summary
      smart00050
      Location:440514
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:518659
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:223421
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:223423
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:72164
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_001261465.2NP_001248394.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 8 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two alternate in-frame exons in the 3' coding region compared to variant 6. The resulting protein (isoform 8) is shorter compared to isoform 6.
      Source sequence(s)
      AL691442, AY560595, BM971880
      Consensus CDS
      CCDS58032.1
      UniProtKB/TrEMBL
      B7Z390
      Related
      ENSP00000357397.3, ENST00000368412.7
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    3. NM_001261466.2NP_001248395.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 9 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences in the 5' coding region and differs in the 3' coding region and UTR compared to variant 6. The resulting protein (isoform 9) is shorter and has a distinct C-terminus compared to isoform 6.
      Source sequence(s)
      AK297468, AL451085, AL691442, AW290953
      Consensus CDS
      CCDS60282.1
      UniProtKB/Swiss-Prot
      Q13444
      Related
      ENSP00000476000.1, ENST00000447332.3
      Conserved Domains (5) summary
      smart00050
      Location:414488
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:492624
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:197395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:197397
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:72138
      Pep_M12B_propep; Reprolysin family propeptide
    4. NM_003815.5NP_003806.3  disintegrin and metalloproteinase domain-containing protein 15 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_003806.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame coding exons compared to variant 6. The resulting isoform (2) lacks an internal region, as compared to the longest isoform (6).
      Source sequence(s)
      AY518542, BC014566, U41767
      Consensus CDS
      CCDS1084.1
      UniProtKB/TrEMBL
      Q59GF2
      Related
      ENSP00000271836.6, ENST00000271836.10
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    5. NM_207191.3NP_997074.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_997074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks three exons in the coding region compared to variant 6, one of which causes a translation frameshift. The resulting isoform (1) has a distinct and shorter C-terminus, as compared to the longest isoform (6).
      Source sequence(s)
      AY518542, AY560593, BM971880
      Consensus CDS
      CCDS1088.1
      UniProtKB/TrEMBL
      B7Z390
      Related
      ENSP00000353892.4, ENST00000360674.8
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    6. NM_207194.3NP_997077.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_997077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 6. The resulting isoform (3) lacks an internal region, as compared to the longest isoform 6.
      Source sequence(s)
      AY518542, AY560593, AY560596, U41767
      Consensus CDS
      CCDS1085.1
      UniProtKB/TrEMBL
      Q59GF2
      Related
      ENSP00000348227.2, ENST00000355956.6
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    7. NM_207195.3NP_997078.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 4 preproprotein

      See identical proteins and their annotated locations for NP_997078.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two in-frame coding exons compared to variant 6. The resulting isoform (4) lacks an internal region, as compared to the longest isoform (6).
      Source sequence(s)
      AY518542, AY560593, AY560597, U41767
      Consensus CDS
      CCDS1086.1
      UniProtKB/TrEMBL
      Q59GF2
      Related
      ENSP00000352226.4, ENST00000359280.8
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    8. NM_207196.3NP_997079.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 5 preproprotein

      See identical proteins and their annotated locations for NP_997079.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternative splice site within the coding region compared to variant 6. The translation frame remains the same. The resulting isoform (5) lacks an amino acid, as compared to the longest isoform (6).
      Source sequence(s)
      AY518542, AY560593, AY560598, U41767
      Consensus CDS
      CCDS44236.1
      UniProtKB/TrEMBL
      Q59GF2
      Related
      ENSP00000403843.2, ENST00000449910.6
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide
    9. NM_207197.3NP_997080.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein

      See identical proteins and their annotated locations for NP_997080.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (6).
      Source sequence(s)
      AY518542, AY560593, AY560599, U41767
      Consensus CDS
      CCDS1087.1
      UniProtKB/Swiss-Prot
      B3KQU5, B4DLB5, B4DMH8, E9PN65, Q13444, Q13493, Q53XQ0, Q5SR68, Q5SR69, Q6R267, Q71S61, Q71S62, Q71S63, Q71S64, Q71S65, Q71S66, Q71S67, Q71S68, Q71S69, Q96C78, U3KQL5
      UniProtKB/TrEMBL
      Q59GF2
      Related
      ENSP00000349436.2, ENST00000356955.7
      Conserved Domains (5) summary
      smart00050
      Location:430504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508649
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:213413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62154
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. NR_048577.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses two alternate splice sites in 3' exons compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL691442, AY560600, BM971880
    2. NR_048578.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate splice site in a 3' exon compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL691442, AY560601, BM971880
      Related
      ENST00000526491.5
    3. NR_048579.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks an exon and uses an alternate splice site in a 3' exon compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL691442, AY576417, BM971880
      Related
      ENST00000529473.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155051316..155062775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154190701..154202162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)