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    GOLGB1 golgin B1 [ Homo sapiens (human) ]

    Gene ID: 2804, updated on 3-Dec-2024

    Summary

    Official Symbol
    GOLGB1provided by HGNC
    Official Full Name
    golgin B1provided by HGNC
    Primary source
    HGNC:HGNC:4429
    See related
    Ensembl:ENSG00000173230 MIM:602500; AllianceGenome:HGNC:4429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP; GCP372; GOLIM1
    Summary
    Enables RNA binding activity. Involved in protein localization to pericentriolar material. Located in Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.1), prostate (RPKM 15.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GOLGB1 in Genome Data Viewer
    Location:
    3q13.33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (121663201..121749966, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (124383093..124471671, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121382048..121468588, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20346 Neighboring gene RNA, 7SL, cytoplasmic 172, pseudogene Neighboring gene RNA, U4 small nuclear 62, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:121449808-121451007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20348 Neighboring gene IQ motif containing B1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20349 Neighboring gene ELL associated factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37232, DKFZp686F09142

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein localization to pericentriolar material IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in Golgi stack TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    golgin subfamily B member 1
    Names
    372 kDa Golgi complex-associated protein
    giantin
    golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
    golgi integral membrane protein 1
    golgin B1, golgi integral membrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256486.2NP_001243415.1  golgin subfamily B member 1 isoform 1

      See identical proteins and their annotated locations for NP_001243415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA127633, AB371588, AB593126, BP320001
      Consensus CDS
      CCDS58847.1
      UniProtKB/TrEMBL
      C9J8Q0
      Related
      ENSP00000377275.3, ENST00000393667.8
      Conserved Domains (4) summary
      COG1196
      Location:8141650
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:19042778
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13942326
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11601223
      Ax_dynein_light; Axonemal dynein light chain
    2. NM_001256487.2NP_001243416.1  golgin subfamily B member 1 isoform 3

      See identical proteins and their annotated locations for NP_001243416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA127633, AB593126, BP320001, D25542
      UniProtKB/TrEMBL
      C9J8Q0
      Conserved Domains (4) summary
      COG1196
      Location:7751611
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18652739
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13552287
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11211184
      Ax_dynein_light; Axonemal dynein light chain
    3. NM_001256488.2NP_001243417.1  golgin subfamily B member 1 isoform 4

      See identical proteins and their annotated locations for NP_001243417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also lacks an internal in-frame exon and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AA127633, AB593126, X75304
      UniProtKB/TrEMBL
      A0A8Q3WKA7
      Conserved Domains (4) summary
      COG1196
      Location:7341570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18242698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13142246
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:10801143
      Ax_dynein_light; Axonemal dynein light chain
    4. NM_001366282.2NP_001353211.1  golgin subfamily B member 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC119736, AC133750
      Consensus CDS
      CCDS93348.1
      UniProtKB/TrEMBL
      A0A8J9C4H3, C9J8Q0
      Related
      ENSP00000484083.2, ENST00000614479.5
      Conserved Domains (1) summary
      cl25732
      Location:13172187
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001366283.2NP_001353212.1  golgin subfamily B member 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC119736, AC133750
      Consensus CDS
      CCDS93347.1
      UniProtKB/TrEMBL
      A0A8Q3WKA7, E7EU81
      Related
      ENSP00000418231.2, ENST00000494517.6
      Conserved Domains (1) summary
      cl25732
      Location:12762146
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001366284.2NP_001353213.1  golgin subfamily B member 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC119736, AC133750
      UniProtKB/TrEMBL
      A0A8Q3WKA7
      Conserved Domains (1) summary
      cl25732
      Location:12372107
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_001389631.1NP_001376560.1  golgin subfamily B member 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC119736, AC133750
      UniProtKB/TrEMBL
      A0A8Q3SHH2
      Conserved Domains (2) summary
      COG1196
      Location:12722142
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:151979
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    8. NM_004487.5NP_004478.3  golgin subfamily B member 1 isoform 2

      See identical proteins and their annotated locations for NP_004478.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA127633, AB593126, X75304
      Consensus CDS
      CCDS3004.1
      UniProtKB/Swiss-Prot
      B2ZZ91, D3DN92, E7EP74, F1T0J2, Q14398, Q14789
      UniProtKB/TrEMBL
      C9J8Q0
      Related
      ENSP00000341848.5, ENST00000340645.10
      Conserved Domains (4) summary
      COG1196
      Location:8091645
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18992773
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13892321
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11551218
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      121663201..121749966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447994.1XP_047303950.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
    2. XM_047447992.1XP_047303948.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
    3. XM_047447989.1XP_047303945.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
    4. XM_047447988.1XP_047303944.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
    5. XM_011512699.4XP_011511001.1  golgin subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_011511001.1

      UniProtKB/TrEMBL
      C9J8Q0
      Conserved Domains (4) summary
      COG1196
      Location:8141650
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:19042778
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13942326
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11601223
      Ax_dynein_light; Axonemal dynein light chain
    6. XM_047447995.1XP_047303951.1  golgin subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      H0Y867
      Related
      ENSP00000417767.2, ENST00000489400.2
    7. XM_006713591.3XP_006713654.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
      Conserved Domains (4) summary
      COG1196
      Location:7341570
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18242698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13142246
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:10801143
      Ax_dynein_light; Axonemal dynein light chain
    8. XM_005247373.3XP_005247430.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
      Conserved Domains (4) summary
      COG1196
      Location:7731609
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18632737
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13532285
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11191182
      Ax_dynein_light; Axonemal dynein light chain
    9. XM_047447990.1XP_047303946.1  golgin subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3SHH2
      Related
      ENSP00000511618.1, ENST00000694958.1
    10. XM_006713589.3XP_006713652.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
      Conserved Domains (4) summary
      COG1196
      Location:8081644
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18982772
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13882320
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11541217
      Ax_dynein_light; Axonemal dynein light chain
    11. XM_006713588.3XP_006713651.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
      Conserved Domains (4) summary
      COG1196
      Location:8091645
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18992773
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13892321
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11551218
      Ax_dynein_light; Axonemal dynein light chain
    12. XM_047447993.1XP_047303949.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
    13. XM_017006191.2XP_016861680.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
      Related
      ENSP00000511640.1, ENST00000695008.1
      Conserved Domains (4) summary
      COG1196
      Location:7731609
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18632737
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13532285
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11191182
      Ax_dynein_light; Axonemal dynein light chain
    14. XM_017006190.2XP_016861679.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
      Related
      ENSP00000511648.1, ENST00000695017.1
      Conserved Domains (4) summary
      COG1196
      Location:8081644
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18982772
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13882320
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11541217
      Ax_dynein_light; Axonemal dynein light chain
    15. XM_017006189.2XP_016861678.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
      Conserved Domains (4) summary
      COG1196
      Location:8091645
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:18992773
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13892321
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11551218
      Ax_dynein_light; Axonemal dynein light chain
    16. XM_047447987.1XP_047303943.1  golgin subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8J9C4H3, C9J8Q0
    17. XM_005247371.5XP_005247428.1  golgin subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_005247428.1

      UniProtKB/TrEMBL
      C9J8Q0
      Conserved Domains (4) summary
      COG1196
      Location:8141650
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:19042778
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:13942326
      Myosin_tail_1; Myosin tail
      pfam10211
      Location:11601223
      Ax_dynein_light; Axonemal dynein light chain
    18. XM_047447991.1XP_047303947.1  golgin subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      C9J8Q0
    19. XM_017006195.2XP_016861684.1  golgin subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      A0A8Q3SHP0
      Related
      ENSP00000511621.1, ENST00000694973.1
    20. XM_047447996.1XP_047303952.1  golgin subfamily B member 1 isoform X11

      UniProtKB/TrEMBL
      C9J8Q0
      Related
      ENSP00000511622.1, ENST00000694974.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      124383093..124471671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346237.1XP_054202212.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
    2. XM_054346234.1XP_054202209.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
    3. XM_054346229.1XP_054202204.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
    4. XM_054346226.1XP_054202201.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
    5. XM_054346222.1XP_054202197.1  golgin subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      C9J8Q0
    6. XM_054346224.1XP_054202199.1  golgin subfamily B member 1 isoform X3

      UniProtKB/TrEMBL
      C9J8Q0
    7. XM_054346221.1XP_054202196.1  golgin subfamily B member 1 isoform X1

      UniProtKB/TrEMBL
      C9J8Q0
    8. XM_054346236.1XP_054202211.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
    9. XM_054346233.1XP_054202208.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
    10. XM_054346228.1XP_054202203.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
    11. XM_054346225.1XP_054202200.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
    12. XM_054346238.1XP_054202213.1  golgin subfamily B member 1 isoform X9

      UniProtKB/TrEMBL
      H0Y867
    13. XM_054346235.1XP_054202210.1  golgin subfamily B member 1 isoform X8

      UniProtKB/TrEMBL
      H0Y867
    14. XM_054346232.1XP_054202207.1  golgin subfamily B member 1 isoform X7

      UniProtKB/TrEMBL
      A0A8Q3WKA7
    15. XM_054346230.1XP_054202205.1  golgin subfamily B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3SHH2
    16. XM_054346227.1XP_054202202.1  golgin subfamily B member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8Q3SHH2
    17. XM_054346223.1XP_054202198.1  golgin subfamily B member 1 isoform X2

      UniProtKB/TrEMBL
      C9J8Q0
    18. XM_054346231.1XP_054202206.1  golgin subfamily B member 1 isoform X6

      UniProtKB/TrEMBL
      C9J8Q0
    19. XM_054346239.1XP_054202214.1  golgin subfamily B member 1 isoform X10

      UniProtKB/TrEMBL
      A0A8Q3SHP0
    20. XM_054346240.1XP_054202215.1  golgin subfamily B member 1 isoform X11

      UniProtKB/TrEMBL
      C9J8Q0