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    ZP2 zona pellucida glycoprotein 2 [ Homo sapiens (human) ]

    Gene ID: 7783, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZP2provided by HGNC
    Official Full Name
    zona pellucida glycoprotein 2provided by HGNC
    Primary source
    HGNC:HGNC:13188
    See related
    Ensembl:ENSG00000103310 MIM:182888; AllianceGenome:HGNC:13188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZPA; Zp-2; OOMD6; OZEMA6
    Summary
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZP2 in Genome Data Viewer
    Location:
    16p12.3-p12.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (21197450..21214510, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (21128399..21145450, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21208771..21225831, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 3 Neighboring gene uncharacterized LOC107984888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10547 Neighboring gene Sharpr-MPRA regulatory region 1818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21170492-21170992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10549 Neighboring gene lipid droplet assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10551 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21233480-21234004 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21234005-21234530 Neighboring gene uncharacterized LOC105371123 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acrosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of egg coat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of egg coat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in prevention of polyspermy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prevention of polyspermy ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT involved_in regulation of acrosome reaction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in egg coat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in multivesicular body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 2
    Names
    zona pellucida 2
    zona pellucida glycoprotein 2 (sperm receptor)
    zona pellucida glycoprotein ZP2
    zona pellucida protein A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376231.1NP_001363160.1  zona pellucida sperm-binding protein 2 isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AF001550, BC096305
      Conserved Domains (1) summary
      pfam00100
      Location:372622
      Zona_pellucida; Zona pellucida-like domain
    2. NM_001376232.1NP_001363161.1  zona pellucida sperm-binding protein 2 isoform 1 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AF001550, AK313003
      Consensus CDS
      CCDS10596.1
      UniProtKB/Swiss-Prot
      B2R7J2, Q05996, Q4VAN9, Q4VAP0, Q4VAP1
      Related
      ENSP00000458991.2, ENST00000574091.6
      Conserved Domains (1) summary
      pfam00100
      Location:372631
      Zona_pellucida; Zona pellucida-like domain
    3. NM_001376233.1NP_001363162.1  zona pellucida sperm-binding protein 2 isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AF001550
      Conserved Domains (1) summary
      pfam00100
      Location:372631
      Zona_pellucida; Zona pellucida-like domain
    4. NM_003460.2NP_003451.1  zona pellucida sperm-binding protein 2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_003451.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF001550, AK310454
      Consensus CDS
      CCDS10596.1
      UniProtKB/Swiss-Prot
      B2R7J2, Q05996, Q4VAN9, Q4VAP0, Q4VAP1
      Related
      ENSP00000460971.1, ENST00000574002.1
      Conserved Domains (1) summary
      pfam00100
      Location:372631
      Zona_pellucida; Zona pellucida-like domain

    RNA

    1. NR_164788.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF001550

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      21197450..21214510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p14 PATCHES

      Range
      21141..38201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      21128399..21145450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290104.1: Suppressed sequence

      Description
      NM_001290104.1: This RefSeq was removed because currently there is support for the protein but not for the transcript.