U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RGS12 regulator of G protein signaling 12 [ Homo sapiens (human) ]

    Gene ID: 6002, updated on 3-Dec-2024

    Summary

    Official Symbol
    RGS12provided by HGNC
    Official Full Name
    regulator of G protein signaling 12provided by HGNC
    Primary source
    HGNC:HGNC:9994
    See related
    Ensembl:ENSG00000159788 MIM:602512; AllianceGenome:HGNC:9994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RGS12 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3285891..3439913)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3284640..3439697)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3287618..3441640)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21218 Neighboring gene RNA, U7 small nuclear 33 pseudogene Neighboring gene huntingtin Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3137138-3137317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15201 Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215178-3215678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215679-3216179 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3239294-3239953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3239954-3240612 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3248264-3248439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3252404-3253300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3271939-3272476 Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3295537-3296122 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3296907-3297102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3306185-3306834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3310051-3310769 Neighboring gene X antigen family member 3 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3319084-3319638 Neighboring gene ribosomal protein L7a pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3374529-3375457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3411075-3411982 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:3417810-3419009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3422145-3422646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3425913-3426412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3434795-3435296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3435297-3435796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3436172-3437070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3437071-3437969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3438515-3439015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3450782-3451585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3463811-3464658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3467576-3468185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3469405-3470012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3474943-3475654 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3476364-3476557 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3481667-3482258 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3482478-3483445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3483446-3484412 Neighboring gene HGF activator Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:3486115-3487314 Neighboring gene docking protein 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761K1617, DKFZp761K1817

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables GTPase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 12
    Names
    regulator of G-protein signalling 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029903.2 RefSeqGene

      Range
      12132..159024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394154.1NP_001381083.1  regulator of G-protein signaling 12 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Related
      ENSP00000338509.4, ENST00000336727.8
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. NM_001394155.1NP_001381084.1  regulator of G-protein signaling 12 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. NM_001394156.1NP_001381085.1  regulator of G-protein signaling 12 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3367.1
      Related
      ENSP00000372238.3, ENST00000382788.7
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    4. NM_001394157.1NP_001381086.1  regulator of G-protein signaling 12 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q56A82
      Conserved Domains (5) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    5. NM_001394158.1NP_001381087.1  regulator of G-protein signaling 12 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q56A82
      Conserved Domains (7) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061137
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    6. NM_001394159.1NP_001381088.1  regulator of G-protein signaling 12 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL645949
      Conserved Domains (4) summary
      PHA03247
      Location:452814
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd21577
      Location:738824
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    7. NM_001394161.1NP_001381090.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:129
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    8. NM_001394162.1NP_001381091.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:129
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    9. NM_001394163.1NP_001381092.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:129
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    10. NM_002926.5NP_002917.1  regulator of G-protein signaling 12 isoform 2

      See identical proteins and their annotated locations for NP_002917.1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3367.1
      UniProtKB/Swiss-Prot
      O14924
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    11. NM_198227.2NP_937870.1  regulator of G-protein signaling 12 isoform 3

      See identical proteins and their annotated locations for NP_937870.1

      Status: REVIEWED

      Source sequence(s)
      AF030109, AF030112, BM984992, CB242608
      Consensus CDS
      CCDS3368.1
      UniProtKB/TrEMBL
      Q506M0
      Related
      ENSP00000342133.4, ENST00000338806.4
      Conserved Domains (7) summary
      smart00455
      Location:387456
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:315387
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08742
      Location:68182
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      pfam02188
      Location:540561
      GoLoco; GoLoco motif
      pfam16611
      Location:458528
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:606726
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:188285
      RGS12_us1; Unstructured region of RGS12
    12. NM_198229.3NP_937872.1  regulator of G-protein signaling 12 isoform 1

      See identical proteins and their annotated locations for NP_937872.1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Related
      ENSP00000339381.5, ENST00000344733.9
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      3285891..3439913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513543.3XP_011511845.1  regulator of G-protein signaling 12 isoform X5

      See identical proteins and their annotated locations for XP_011511845.1

      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:129
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_047416060.1XP_047272016.1  regulator of G-protein signaling 12 isoform X7

      UniProtKB/TrEMBL
      B3KVS7
    3. XM_017008529.3XP_016864018.1  regulator of G-protein signaling 12 isoform X1

      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Conserved Domains (9) summary
      cd08742
      Location:716830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:11881209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:2096
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:9621031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:11061180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:12391376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:10321104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    4. XM_047416055.1XP_047272011.1  regulator of G-protein signaling 12 isoform X2

      UniProtKB/TrEMBL
      Q56A82
    5. XM_047416056.1XP_047272012.1  regulator of G-protein signaling 12 isoform X3

      UniProtKB/TrEMBL
      Q56A82
    6. XM_047416057.1XP_047272013.1  regulator of G-protein signaling 12 isoform X4

    7. XM_017008534.2XP_016864023.1  regulator of G-protein signaling 12 isoform X6

    8. XM_047416058.1XP_047272014.1  regulator of G-protein signaling 12 isoform X5

      UniProtKB/TrEMBL
      Q506M0
    9. XM_047416059.1XP_047272015.1  regulator of G-protein signaling 12 isoform X5

      UniProtKB/TrEMBL
      Q506M0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      3284640..3439697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350686.1XP_054206661.1  regulator of G-protein signaling 12 isoform X5

      UniProtKB/TrEMBL
      Q506M0
    2. XM_054350688.1XP_054206663.1  regulator of G-protein signaling 12 isoform X7

      UniProtKB/TrEMBL
      B3KVS7
    3. XM_054350682.1XP_054206657.1  regulator of G-protein signaling 12 isoform X1

      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
    4. XM_054350683.1XP_054206658.1  regulator of G-protein signaling 12 isoform X2

      UniProtKB/TrEMBL
      Q56A82
    5. XM_054350685.1XP_054206660.1  regulator of G-protein signaling 12 isoform X3

      UniProtKB/TrEMBL
      Q56A82
    6. XM_054350684.1XP_054206659.1  regulator of G-protein signaling 12 isoform X8

    7. XM_054350687.1XP_054206662.1  regulator of G-protein signaling 12 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198230.1: Suppressed sequence

      Description
      NM_198230.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_198430.1: Suppressed sequence

      Description
      NM_198430.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_198432.1: Suppressed sequence

      Description
      NM_198432.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_198587.1: Suppressed sequence

      Description
      NM_198587.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.