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    TSPAN5 tetraspanin 5 [ Homo sapiens (human) ]

    Gene ID: 10098, updated on 10-Dec-2024

    Summary

    Official Symbol
    TSPAN5provided by HGNC
    Official Full Name
    tetraspanin 5provided by HGNC
    Primary source
    HGNC:HGNC:17753
    See related
    Ensembl:ENSG00000168785 MIM:613136; AllianceGenome:HGNC:17753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET4; NET-4; TM4SF9; TSPAN-5
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSPAN5 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98470367..98658611, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (101785330..101973565, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99391518..99579762, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene uncharacterized LOC124900919 Neighboring gene ribosomal protein L21 pseudogene 48 Neighboring gene Sharpr-MPRA regulatory region 12770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:99457519-99458032 Neighboring gene Sharpr-MPRA regulatory region 11258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:99518736-99519334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:99574420-99575619 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:99579327-99579486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15578 Neighboring gene uncharacterized LOC112267901 Neighboring gene TSPAN5 divergent transcript Neighboring gene CRISPRi-validated cis-regulatory element chr4.2289 Neighboring gene CRISPRi-validated cis-regulatory element chr4.2290 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tetraspanin 5 (TSPAN5) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tetraspanin-5
    Names
    tetraspan NET-4
    tetraspan TM4SF
    transmembrane 4 superfamily member 9
    transmembrane 4 superfamily, member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046902.1 RefSeqGene

      Range
      5051..193295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005723.4NP_005714.2  tetraspanin-5

      See identical proteins and their annotated locations for NP_005714.2

      Status: REVIEWED

      Source sequence(s)
      AC058823, AC114811, AI089708, BC009704
      Consensus CDS
      CCDS3646.1
      UniProtKB/Swiss-Prot
      B2RDY2, O60628, O60746, P62079, Q6FHE5, Q9JLY1
      UniProtKB/TrEMBL
      Q6FHC5
      Related
      ENSP00000307701.3, ENST00000305798.8
      Conserved Domains (2) summary
      cd03159
      Location:113233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:15257
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      98470367..98658611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262680.2XP_005262737.1  tetraspanin-5 isoform X1

      See identical proteins and their annotated locations for XP_005262737.1

      UniProtKB/TrEMBL
      Q6FHC5
      Conserved Domains (1) summary
      cd03159
      Location:64184
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    2. XM_047449475.1XP_047305431.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317
      Related
      ENSP00000423916.1, ENST00000505184.5
    3. XM_047449473.1XP_047305429.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317
    4. XM_047449472.1XP_047305428.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317
    5. XM_047449477.1XP_047305433.1  tetraspanin-5 isoform X4

    6. XM_047449476.1XP_047305432.1  tetraspanin-5 isoform X3

      UniProtKB/TrEMBL
      D6RAR1
      Related
      ENSP00000421808.1, ENST00000508798.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      101785330..101973565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348694.1XP_054204669.1  tetraspanin-5 isoform X1

      UniProtKB/TrEMBL
      Q6FHC5
    2. XM_054348695.1XP_054204670.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317
    3. XM_054348697.1XP_054204672.1  tetraspanin-5 isoform X4

    4. XM_054348696.1XP_054204671.1  tetraspanin-5 isoform X3

      UniProtKB/TrEMBL
      D6RAR1