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    TSPAN5 tetraspanin 5 [ Homo sapiens (human) ]

    Gene ID: 10098, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TSPAN5provided by HGNC
    Official Full Name
    tetraspanin 5provided by HGNC
    Primary source
    HGNC:HGNC:17753
    See related
    Ensembl:ENSG00000168785 MIM:613136; AllianceGenome:HGNC:17753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET4; NET-4; TM4SF9; TSPAN-5
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 32.0), ovary (RPKM 24.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TSPAN5 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98470367..98658611, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (101785330..101973565, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99391518..99579762, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene uncharacterized LOC124900919 Neighboring gene ribosomal protein L21 pseudogene 48 Neighboring gene Sharpr-MPRA regulatory region 12770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:99457519-99458032 Neighboring gene Sharpr-MPRA regulatory region 11258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:99518736-99519334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:99574420-99575619 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:99579327-99579486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15578 Neighboring gene uncharacterized LOC112267901 Neighboring gene TSPAN5 divergent transcript Neighboring gene CRISPRi-validated cis-regulatory element chr4.2289 Neighboring gene CRISPRi-validated cis-regulatory element chr4.2290 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The relationship between expression of Tspan5 mRNA in maternal-fetal interface and tubal pregnancy. Wei S, et al. Eur J Obstet Gynecol Reprod Biol, 2024 May. PMID 38422804
    2. Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling. Xie Q, et al. Mol Oncol, 2021 Nov. PMID 33955149, Free PMC Article
    3. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Ho MF, et al. Mol Psychiatry, 2021 Jul. PMID 32753686, Free PMC Article
    4. The increased level of Tspan5 in villi suggests more proliferation and invasiveness of trophoblasts in tubal pregnancy. Gao T, et al. Eur J Obstet Gynecol Reprod Biol, 2018 Sep. PMID 29908376
    5. Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer. He P, et al. Oncotarget, 2016 Jun 28. PMID 27223087, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The relationship between expression of Tspan5 mRNA in maternal-fetal interface and tubal pregnancy.
      Title: The relationship between expression of Tspan5 mRNA in maternal-fetal interface and tubal pregnancy.
    2. Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
      Title: Tspan5 promotes epithelial-mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling.
    3. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
      Title: TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
    4. TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
      Title: TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
    5. Data show that gene tetraspanin-5 (TSPAN5) is the target of miR-155 in breast cancer (BC).
      Title: miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5.
    6. intensity in villi in tubal pregnancy was significantly higher than that in normal intrauterine pregnancy
      Title: The increased level of Tspan5 in villi suggests more proliferation and invasiveness of trophoblasts in tubal pregnancy.
    7. Tspan5 may serve as a prognostic biomarker for predicting outcome of gastric cancer patients. Tspan5 functions as a tumour suppressor in stomach to control the tumour growth.
      Title: Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer.
    8. Endothelial Tspan5- and Tspan17-ADAM10 complexes may regulate inflammation by maintaining normal VE-cadherin expression and promoting T lymphocyte transmigration.
      Title: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
    9. two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for ADAM10 interaction and exit from the endoplasmic reticulum. One of the anti-Tspan5 mAbs does not recognize Tspan5 associated with ADAM10, providing a convenient way to measure the fraction of Tspan5 not associated with ADAM10.
      Title: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tetraspanin 5 (TSPAN5) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-5
    Names
    tetraspan NET-4
    tetraspan TM4SF
    transmembrane 4 superfamily member 9
    transmembrane 4 superfamily, member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046902.1 RefSeqGene

      Range
      5051..193295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005723.4 → NP_005714.2  tetraspanin-5

      See identical proteins and their annotated locations for NP_005714.2

      Status: REVIEWED

      Source sequence(s)
      AC058823, AC114811, AI089708, BC009704
      Consensus CDS
      CCDS3646.1
      UniProtKB/Swiss-Prot
      B2RDY2, O60628, O60746, P62079, Q6FHE5, Q9JLY1
      UniProtKB/TrEMBL
      Q6FHC5
      Related
      ENSP00000307701.3, ENST00000305798.8
      Conserved Domains (2) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:15 → 257
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      98470367..98658611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262680.2 → XP_005262737.1  tetraspanin-5 isoform X1

      See identical proteins and their annotated locations for XP_005262737.1

      UniProtKB/TrEMBL
      Q6FHC5
      Conserved Domains (1) summary
      cd03159
      Location:64 → 184
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. XM_047449475.1 → XP_047305431.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317
      Related
      ENSP00000423916.1, ENST00000505184.5

    3. XM_047449473.1 → XP_047305429.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317

    4. XM_047449472.1 → XP_047305428.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317

    5. XM_047449477.1 → XP_047305433.1  tetraspanin-5 isoform X4

    6. XM_047449476.1 → XP_047305432.1  tetraspanin-5 isoform X3

      UniProtKB/TrEMBL
      D6RAR1
      Related
      ENSP00000421808.1, ENST00000508798.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      101785330..101973565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348694.1 → XP_054204669.1  tetraspanin-5 isoform X1

      UniProtKB/TrEMBL
      Q6FHC5

    2. XM_054348695.1 → XP_054204670.1  tetraspanin-5 isoform X2

      UniProtKB/TrEMBL
      B7Z317

    3. XM_054348697.1 → XP_054204672.1  tetraspanin-5 isoform X4

    4. XM_054348696.1 → XP_054204671.1  tetraspanin-5 isoform X3

      UniProtKB/TrEMBL
      D6RAR1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62079.1 GenPept UniProtKB/Swiss-Prot:P62079

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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