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    LILRA2 leukocyte immunoglobulin like receptor A2 [ Homo sapiens (human) ]

    Gene ID: 11027, updated on 3-Dec-2024

    Summary

    Official Symbol
    LILRA2provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor A2provided by HGNC
    Primary source
    HGNC:HGNC:6603
    See related
    Ensembl:ENSG00000239998 MIM:604812; AllianceGenome:HGNC:6603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILT1; LIR7; CD85H; LIR-7
    Summary
    This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
    Expression
    Biased expression in bone marrow (RPKM 15.6), spleen (RPKM 8.6) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LILRA2 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54572988..54590287)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57666505..57683802)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55084455..55101752)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene) Neighboring gene uncharacterized LOC105372461 Neighboring gene uncharacterized LOC107985347 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene leukocyte immunoglobulin like receptor B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgM binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response activating cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-10-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of granulocyte colony-stimulating factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of granulocyte macrophage colony-stimulating factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily A member 2
    Names
    CD85 antigen-like family member H
    immunoglobulin-like transcript 1
    leucocyte Ig-like receptor A2
    leukocyte immunoglobulin-like receptor 7
    leukocyte immunoglobulin-like receptor subfamily A member 2 soluble
    leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034038.2 RefSeqGene

      Range
      5804..22301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130917.3NP_001124389.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001124389.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, U82278
      Consensus CDS
      CCDS46179.1
      UniProtKB/Swiss-Prot
      O75020, Q8N149
      UniProtKB/TrEMBL
      A0A0G2JMW8
      Related
      ENSP00000375618.3, ENST00000391738.8
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:27117
      Ig; Immunoglobulin domain
    2. NM_001290270.1NP_001277199.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform c precursor

      See identical proteins and their annotated locations for NP_001277199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks in-frame exons in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, U82276
      Consensus CDS
      CCDS74453.1
      UniProtKB/TrEMBL
      A0A0G2JMW8, A8MZH0
      Related
      ENSP00000375617.1, ENST00000391737.3
      Conserved Domains (2) summary
      smart00410
      Location:23104
      IG_like; Immunoglobulin like
      cl11960
      Location:15105
      Ig; Immunoglobulin domain
    3. NM_001290271.2NP_001277200.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform d precursor

      See identical proteins and their annotated locations for NP_001277200.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and lacks an exon and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, DA264697
      UniProtKB/TrEMBL
      A0A0G2JMC9
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain
    4. NM_006866.4NP_006857.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC245036, BC027916, CB046242, DA465773, DA931441
      Consensus CDS
      CCDS12900.1
      UniProtKB/TrEMBL
      A0A0G2JMW8
      Related
      ENSP00000251376.3, ENST00000251376.7
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:27117
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54572988..54590287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438112.1XP_047294068.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMW8
    2. XM_011526390.2XP_011524692.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      UniProtKB/TrEMBL
      E9PDF4
      Related
      ENSP00000388131.1, ENST00000439534.5
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain
    3. XM_011526391.2XP_011524693.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      479378..496677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329647.1XP_054185622.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMW8
    2. XM_054329648.1XP_054185623.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JMR2
    3. XM_054329649.1XP_054185624.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      477872..495171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331474.1XP_054187449.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMW8
    2. XM_054331475.1XP_054187450.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JMR2
    3. XM_054331476.1XP_054187451.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      555569..572866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333610.1XP_054189585.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMW8
    2. XM_054333611.1XP_054189586.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JMR2
    3. XM_054333612.1XP_054189587.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57666505..57683802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319655.1XP_054175630.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JMW8
    2. XM_054319656.1XP_054175631.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JMR2
    3. XM_054319657.1XP_054175632.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3