U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MIIP migration and invasion inhibitory protein [ Homo sapiens (human) ]

    Gene ID: 60672, updated on 9-Dec-2024

    Summary

    Official Symbol
    MIIPprovided by HGNC
    Official Full Name
    migration and invasion inhibitory proteinprovided by HGNC
    Primary source
    HGNC:HGNC:25715
    See related
    Ensembl:ENSG00000116691 MIM:608772; AllianceGenome:HGNC:25715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IIP45
    Summary
    This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MIIP in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12019498..12032045)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11563622..11576189)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12079555..12092102)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11994483-11995406 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:11998825-12000024 Neighboring gene Sharpr-MPRA regulatory region 8260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12005168-12005843 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12023296-12023497 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026474-12026974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026975-12027475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12060855-12061784 Neighboring gene mitofusin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12065587-12065864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12067964-12068629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12068630-12069294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12079342-12080212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12080213-12081083 Neighboring gene CRISPRi-validated cis-regulatory element chr1.1957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 188 Neighboring gene microRNA 6729 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 197 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12122803-12123035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 199 Neighboring gene TNF receptor superfamily member 8 Neighboring gene RNA, U6 small nuclear 777, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef-mediated downregulation of HLA (MHCI) may be affected by/inhibited by' MIIP as demonstrated by siRNA genome-wide screen [in HeLa cells) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    migration and invasion-inhibitory protein
    Names
    IGFBP2-binding protein
    invasion-inhibitory protein 45

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030022.2 RefSeqGene

      Range
      5257..17804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021933.4NP_068752.2  migration and invasion-inhibitory protein

      See identical proteins and their annotated locations for NP_068752.2

      Status: REVIEWED

      Source sequence(s)
      FJ618905
      Consensus CDS
      CCDS143.1
      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Related
      ENSP00000235332.4, ENST00000235332.6
      Conserved Domains (1) summary
      pfam15734
      Location:66378
      MIIP; Migration and invasion-inhibitory

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      12019498..12032045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541895.2XP_011540197.1  migration and invasion-inhibitory protein isoform X1

      See identical proteins and their annotated locations for XP_011540197.1

      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Conserved Domains (1) summary
      pfam15734
      Location:66378
      MIIP; Migration and invasion-inhibitory
    2. XM_011541896.2XP_011540198.1  migration and invasion-inhibitory protein isoform X1

      See identical proteins and their annotated locations for XP_011540198.1

      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Conserved Domains (1) summary
      pfam15734
      Location:66378
      MIIP; Migration and invasion-inhibitory
    3. XM_005263487.5XP_005263544.1  migration and invasion-inhibitory protein isoform X2

      Conserved Domains (1) summary
      pfam15734
      Location:66366
      MIIP; Migration and invasion-inhibitory

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11563622..11576189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338078.1XP_054194053.1  migration and invasion-inhibitory protein isoform X2

    2. XM_054338077.1XP_054194052.1  migration and invasion-inhibitory protein isoform X1

    3. XM_054338076.1XP_054194051.1  migration and invasion-inhibitory protein isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025374.1: Suppressed sequence

      Description
      NM_001025374.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.