U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EXOC1 exocyst complex component 1 [ Homo sapiens (human) ]

    Gene ID: 55763, updated on 9-Dec-2024

    Summary

    Official Symbol
    EXOC1provided by HGNC
    Official Full Name
    exocyst complex component 1provided by HGNC
    Primary source
    HGNC:HGNC:30380
    See related
    Ensembl:ENSG00000090989 MIM:607879; AllianceGenome:HGNC:30380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC3; SEC3P; BM-102; SEC3L1
    Summary
    The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 10.9), skin (RPKM 9.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EXOC1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55853648..55905086)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59341793..59393237)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56719814..56771252)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377661 Neighboring gene RNA, U6 small nuclear 276, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56707633-56708266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56708267-56708900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15445 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:56726227-56727426 Neighboring gene exocyst complex component 1 like Neighboring gene uncharacterized LOC105377663 Neighboring gene RNA, U6 small nuclear 652, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:56786864-56788063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21575 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:56814688-56815652 Neighboring gene uncharacterized LOC124900705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21576 Neighboring gene centrosomal protein 135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56915160-56915835 Neighboring gene VISTA enhancer hs1651 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56952044-56952696 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene RNA, 5S ribosomal pseudogene 161

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef interacts with EXOC1 and this interaction is dependent on the GTPase interaction site of PAK2 PubMed
    nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 1 (EXOC1) is a Nef-binding protein in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10893

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    exocyst complex component 1
    Names
    SEC3-like 1
    exocyst complex component Sec3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024924.2NP_001020095.1  exocyst complex component 1 isoform 1

      See identical proteins and their annotated locations for NP_001020095.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, as compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC110611, AW589689, BC094751, BM468054
      Consensus CDS
      CCDS3502.1
      UniProtKB/Swiss-Prot
      Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4
      Related
      ENSP00000370695.2, ENST00000381295.7
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184871
      Sec3_C; Exocyst complex component Sec3
    2. NM_018261.4NP_060731.2  exocyst complex component 1 isoform 1

      See identical proteins and their annotated locations for NP_060731.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC110611, AK001755, AW589689, BC094751
      Consensus CDS
      CCDS3502.1
      UniProtKB/Swiss-Prot
      Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4
      Related
      ENSP00000326514.7, ENST00000346134.11
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184871
      Sec3_C; Exocyst complex component Sec3
    3. NM_178237.3NP_839955.1  exocyst complex component 1 isoform 2

      See identical proteins and their annotated locations for NP_839955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) lacks an internal segment and is shorter than isoform 1.
      Source sequence(s)
      AC110611, AK027413, AL833208, AW589689, BC094751
      Consensus CDS
      CCDS3503.1
      Related
      ENSP00000334431.6, ENST00000349598.6
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184856
      Sec3_C; Exocyst complex component Sec3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      55853648..55905086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265747.4XP_005265804.1  exocyst complex component 1 isoform X1

      See identical proteins and their annotated locations for XP_005265804.1

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184889
      Sec3_C; Exocyst complex component Sec3
    2. XM_017008405.3XP_016863894.1  exocyst complex component 1 isoform X2

    3. XM_005265750.4XP_005265807.1  exocyst complex component 1 isoform X3

      See identical proteins and their annotated locations for XP_005265807.1

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184856
      Sec3_C; Exocyst complex component Sec3
    4. XM_005265748.2XP_005265805.1  exocyst complex component 1 isoform X1

      See identical proteins and their annotated locations for XP_005265805.1

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184889
      Sec3_C; Exocyst complex component Sec3
    5. XM_017008406.2XP_016863895.1  exocyst complex component 1 isoform X2

    6. XM_017008407.3XP_016863896.1  exocyst complex component 1 isoform X5

    7. XM_047415961.1XP_047271917.1  exocyst complex component 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      59341793..59393237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350494.1XP_054206469.1  exocyst complex component 1 isoform X1

    2. XM_054350496.1XP_054206471.1  exocyst complex component 1 isoform X2

    3. XM_054350498.1XP_054206473.1  exocyst complex component 1 isoform X3

    4. XM_054350495.1XP_054206470.1  exocyst complex component 1 isoform X1

    5. XM_054350497.1XP_054206472.1  exocyst complex component 1 isoform X2

    6. XM_054350500.1XP_054206475.1  exocyst complex component 1 isoform X5

    7. XM_054350499.1XP_054206474.1  exocyst complex component 1 isoform X4