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    BRMS1L BRMS1 like transcriptional repressor [ Homo sapiens (human) ]

    Gene ID: 84312, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BRMS1Lprovided by HGNC
    Official Full Name
    BRMS1 like transcriptional repressorprovided by HGNC
    Primary source
    HGNC:HGNC:20512
    See related
    Ensembl:ENSG00000100916 MIM:618514; AllianceGenome:HGNC:20512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p40; BRMS1
    Summary
    The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BRMS1L in Genome Data Viewer
    Location:
    14q13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35826338..35871963)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (30014073..30059698)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36295544..36341169)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:36278151-36278711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36288541-36289042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5681 Neighboring gene nuclear transport factor 2 pseudogene 2 Neighboring gene EWS RNA binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5682 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:36416980-36418179 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:36445302-36445956 Neighboring gene uncharacterized LOC105370452 Neighboring gene interleukin enhancer binding factor 2 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Gong C, et al. Nat Commun, 2014 Nov 19. PMID 25406648
    2. Decreased BRMS1L expression is correlated with glioma grade and predicts poor survival in glioblastoma via an invasive phenotype. Lv J, et al. Cancer Biomark, 2018. PMID 29660900
    3. BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway. Cao P, et al. Exp Cell Res, 2018 Oct 1. PMID 30118697
    4. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Nikolaev AY, et al. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451426
    5. Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex. Smith KT, et al. Mol Cell Proteomics, 2012 Dec. PMID 22984288, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11296

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer metastasis-suppressor 1-like protein
    Names
    BRMS1-homolog protein p40
    BRMS1-like protein p40
    breast cancer metastasis-suppressor 1 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032352.4 → NP_115728.2  breast cancer metastasis-suppressor 1-like protein

      See identical proteins and their annotated locations for NP_115728.2

      Status: REVIEWED

      Source sequence(s)
      AA836514, AL162311, BU507838
      Consensus CDS
      CCDS32066.1
      UniProtKB/Swiss-Prot
      A6NFW5, A6NH45, B2RD65, Q5PSV4, Q9BRI4
      UniProtKB/TrEMBL
      B4DLQ5
      Related
      ENSP00000216807.6, ENST00000216807.12
      Conserved Domains (1) summary
      pfam08598
      Location:61 → 177
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      35826338..35871963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431806.1 → XP_047287762.1  breast cancer metastasis-suppressor 1-like protein isoform X2

      UniProtKB/TrEMBL
      B4DLQ5

    2. XM_005268128.2 → XP_005268185.1  breast cancer metastasis-suppressor 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_005268185.1

      UniProtKB/TrEMBL
      B4DLQ5
      Conserved Domains (1) summary
      pfam08598
      Location:61 → 177
      Sds3; Sds3-like

    3. XM_017021705.1 → XP_016877194.1  breast cancer metastasis-suppressor 1-like protein isoform X3

      UniProtKB/TrEMBL
      B4DLQ5
      Conserved Domains (1) summary
      pfam08598
      Location:13 → 129
      Sds3; Sds3-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      30014073..30059698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376810.1 → XP_054232785.1  breast cancer metastasis-suppressor 1-like protein isoform X2

      UniProtKB/TrEMBL
      B4DLQ5

    2. XM_054376809.1 → XP_054232784.1  breast cancer metastasis-suppressor 1-like protein isoform X1

      UniProtKB/TrEMBL
      B4DLQ5

    3. XM_054376811.1 → XP_054232786.1  breast cancer metastasis-suppressor 1-like protein isoform X3

      UniProtKB/TrEMBL
      B4DLQ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PSV4.2 GenPept UniProtKB/Swiss-Prot:Q5PSV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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