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    ZBTB37 zinc finger and BTB domain containing 37 [ Homo sapiens (human) ]

    Gene ID: 84614, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZBTB37provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 37provided by HGNC
    Primary source
    HGNC:HGNC:28365
    See related
    Ensembl:ENSG00000185278 AllianceGenome:HGNC:28365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF908; D430004I08Rik
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 2.8), bone marrow (RPKM 1.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZBTB37 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173868082..173903547)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173226202..173261663)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173837220..173872685)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene growth arrest specific 5 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122770.3NP_001116242.1  zinc finger and BTB domain-containing protein 37 isoform a

      See identical proteins and their annotated locations for NP_001116242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS44278.1
      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Related
      ENSP00000356674.4, ENST00000367701.10
      Conserved Domains (4) summary
      sd00017
      Location:375395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416438
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001346115.2NP_001333044.1  zinc finger and BTB domain-containing protein 37 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the C-terminus compared to isoform a.
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS86033.1
      UniProtKB/Swiss-Prot
      Q5TC79
      UniProtKB/TrEMBL
      B7Z7Z4
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    3. NM_001369846.1NP_001356775.1  zinc finger and BTB domain-containing protein 37 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS86033.1
      Related
      ENSP00000356677.1, ENST00000367704.5
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    4. NM_001395199.1NP_001382128.1  zinc finger and BTB domain-containing protein 37 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS44278.1
      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Related
      ENSP00000511931.1, ENST00000695459.1
      Conserved Domains (4) summary
      sd00017
      Location:375395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416438
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001395200.1NP_001382129.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    6. NM_001395201.1NP_001382130.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    7. NM_001395202.1NP_001382131.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    8. NM_032522.5NP_115911.1  zinc finger and BTB domain-containing protein 37 isoform b

      See identical proteins and their annotated locations for NP_115911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS1312.1
      UniProtKB/Swiss-Prot
      Q5TC79
      Related
      ENSP00000356675.1, ENST00000367702.1
      Conserved Domains (1) summary
      pfam00651
      Location:22122
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173868082..173903547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002557.2XP_016858046.1  zinc finger and BTB domain-containing protein 37 isoform X2

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    2. XM_011510062.4XP_011508364.1  zinc finger and BTB domain-containing protein 37 isoform X2

      See identical proteins and their annotated locations for XP_011508364.1

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    3. XM_006711578.5XP_006711641.1  zinc finger and BTB domain-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_006711641.1

      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Conserved Domains (4) summary
      sd00017
      Location:375395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416438
      zf-H2C2_2; Zinc-finger double domain
    4. XM_047432197.1XP_047288153.1  zinc finger and BTB domain-containing protein 37 isoform X2

    5. XM_017002558.2XP_016858047.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      173226202..173261663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339219.1XP_054195194.1  zinc finger and BTB domain-containing protein 37 isoform X2

    2. XM_054339218.1XP_054195193.1  zinc finger and BTB domain-containing protein 37 isoform X2

    3. XM_054339217.1XP_054195192.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
    4. XM_054339221.1XP_054195196.1  zinc finger and BTB domain-containing protein 37 isoform X2

    5. XM_054339220.1XP_054195195.1  zinc finger and BTB domain-containing protein 37 isoform X3