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    PALD1 phosphatase domain containing paladin 1 [ Homo sapiens (human) ]

    Gene ID: 27143, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PALD1provided by HGNC
    Official Full Name
    phosphatase domain containing paladin 1provided by HGNC
    Primary source
    HGNC:HGNC:23530
    See related
    Ensembl:ENSG00000107719 MIM:614656; AllianceGenome:HGNC:23530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PALD; KIAA1274
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung (RPKM 5.3), spleen (RPKM 4.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PALD1 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (70458485..70568450)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (71327903..71438184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72238523..72328206)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2447 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72194899-72195400 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72197102-72197282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72199683-72200292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72200293-72200900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72200901-72201510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72202121-72202730 Neighboring gene Sharpr-MPRA regulatory region 10829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72210316-72210984 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:72214954-72215480 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72215481-72216006 Neighboring gene nodal growth differentiation factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72232724-72233490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72239853-72240495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72240496-72241137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72242631-72243178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72253375-72254035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72258695-72259456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72259457-72260216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72273197-72273732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72273733-72274267 Neighboring gene Sharpr-MPRA regulatory region 14353 Neighboring gene YY1 transcription factor pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:72288493-72289410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72298034-72298719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72297349-72298033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72301641-72302141 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72318935-72319878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72319879-72320822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72344798-72345298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72345790-72345956 Neighboring gene Sharpr-MPRA regulatory region 12376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72356137-72356637 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:72385043-72385632 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72391517-72392148 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72396829-72397014 Neighboring gene perforin 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17237 Neighboring gene Sharpr-MPRA regulatory region 11165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3511 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2252 Neighboring gene Sharpr-MPRA regulatory region 4371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72442365-72443210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:72447939-72448583 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72453261-72453762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72453763-72454262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72461609-72462110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72462111-72462610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72465820-72466320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72497279-72497778 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17283 Neighboring gene Sharpr-MPRA regulatory region 12298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72502823-72503626 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72516391-72517350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72521542-72522311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Negative regulators of insulin signaling revealed in a genome-wide functional screen. Huang SM, et al. PLoS One, 2009 Sep 3. PMID 19727444, Free PMC Article
    2. Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema. Egaña I, et al. Sci Rep, 2017 Nov 13. PMID 29133847, Free PMC Article
    3. Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease. Sommerer Y, et al. Alzheimers Res Ther, 2023 May 6. PMID 37149695, Free PMC Article
    4. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Wallgard E, et al. Dev Dyn, 2012 Apr. PMID 22354871
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease.
      Title: Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease.
    2. PALD (KIAA1274, paladin) has a role in inhibition of insulin's ability to down regulate a FOXO1A-driven reporter gene, reduce upstream insulin-stimulated AKT phosphorylation, and decrease insulin receptor (IR) abundance
      Title: Negative regulators of insulin signaling revealed in a genome-wide functional screen.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1274

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    paladin
    Names
    palladin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014431.3 → NP_055246.2  paladin

      See identical proteins and their annotated locations for NP_055246.2

      Status: VALIDATED

      Source sequence(s)
      AC022532, AL355344, BC040163, CN335744
      Consensus CDS
      CCDS31215.1
      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1
      Related
      ENSP00000263563.5, ENST00000263563.7
      Conserved Domains (1) summary
      pfam14566
      Location:161 → 330
      PTPlike_phytase; Inositol hexakisphosphate

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      70458485..70568450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539638.3 → XP_011537940.1  paladin isoform X1

      See identical proteins and their annotated locations for XP_011537940.1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1
      Conserved Domains (1) summary
      pfam14566
      Location:161 → 330
      PTPlike_phytase; Inositol hexakisphosphate

    2. XM_047425057.1 → XP_047281013.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    3. XM_047425055.1 → XP_047281011.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    4. XM_047425056.1 → XP_047281012.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    5. XM_047425059.1 → XP_047281015.1  paladin isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL18, A0A8V8TL47
      Related
      ENSP00000513330.1, ENST00000697547.1

    6. XM_047425058.1 → XP_047281014.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    7. XM_011539637.3 → XP_011537939.1  paladin isoform X1

      See identical proteins and their annotated locations for XP_011537939.1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1
      Conserved Domains (1) summary
      pfam14566
      Location:161 → 330
      PTPlike_phytase; Inositol hexakisphosphate

    8. XM_047425060.1 → XP_047281016.1  paladin isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL18, A0A8V8TL47

    9. XM_017016072.2 → XP_016871561.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1
      Conserved Domains (1) summary
      pfam14566
      Location:161 → 330
      PTPlike_phytase; Inositol hexakisphosphate

    RNA

    1. XR_945675.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      71327903..71438184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365549.1 → XP_054221524.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    2. XM_054365550.1 → XP_054221525.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    3. XM_054365545.1 → XP_054221520.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    4. XM_054365548.1 → XP_054221523.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    5. XM_054365547.1 → XP_054221522.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    6. XM_054365546.1 → XP_054221521.1  paladin isoform X1

      UniProtKB/Swiss-Prot
      B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
      UniProtKB/TrEMBL
      A0A8V8TLG1

    RNA

    1. XR_008488196.1 RNA Sequence

    2. XR_008488198.1 RNA Sequence

    3. XR_008488197.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULE6.3 GenPept UniProtKB/Swiss-Prot:Q9ULE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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