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    ATG10 autophagy related 10 [ Homo sapiens (human) ]

    Gene ID: 83734, updated on 3-Dec-2024

    Summary

    Official Symbol
    ATG10provided by HGNC
    Official Full Name
    autophagy related 10provided by HGNC
    Primary source
    HGNC:HGNC:20315
    See related
    Ensembl:ENSG00000152348 MIM:610800; AllianceGenome:HGNC:20315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APG10; APG10L; pp12616
    Summary
    Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ATG10 in Genome Data Viewer
    Location:
    5q14.1-q14.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (81972023..82256133)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (82456197..82741920)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (81267842..81551952)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22733 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:81147710-81148560 Neighboring gene uncharacterized LOC124901018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22734 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:81196818-81197416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:81197417-81198014 Neighboring gene SEM1 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:81267375-81267932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:81267933-81268488 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:81275893-81276450 Neighboring gene Sharpr-MPRA regulatory region 409 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:81278121-81278678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:81278679-81279234 Neighboring gene VISTA enhancer hs1432 Neighboring gene peptidylprolyl isomerase A pseudogene 11 Neighboring gene RNA, 7SL, cytoplasmic 378, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22735 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:81569855-81570549 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:81570550-81571243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22736 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:81589318-81590120 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:81590121-81590923 Neighboring gene ATPase H+ transporting accessory protein 1 like (pseudogene) Neighboring gene ribosomal protein S23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13954, DKFZp586I0418

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Atg12 conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Atg12 conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Atg12 transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ER overload response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein modification by small protein conjugation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like-conjugating enzyme ATG10
    Names
    APG10 autophagy 10-like
    ATG10 autophagy related 10 homolog
    autophagy-related protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131028.2NP_001124500.1  ubiquitin-like-conjugating enzyme ATG10

      See identical proteins and their annotated locations for NP_001124500.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC010598, AC114969, AI436652, AK225969, AL136912
      Consensus CDS
      CCDS4057.1
      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
      Related
      ENSP00000404938.3, ENST00000458350.7
      Conserved Domains (1) summary
      pfam03987
      Location:100167
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    2. NM_031482.5NP_113670.1  ubiquitin-like-conjugating enzyme ATG10

      See identical proteins and their annotated locations for NP_113670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC010598, AC114969, AI436652, AK225969, BC029268
      Consensus CDS
      CCDS4057.1
      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
      Related
      ENSP00000282185.3, ENST00000282185.8
      Conserved Domains (1) summary
      pfam03987
      Location:100167
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      81972023..82256133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417800.1XP_047273756.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    2. XM_047417803.1XP_047273759.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    3. XM_017009944.2XP_016865433.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
      Conserved Domains (1) summary
      pfam03987
      Location:64131
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    4. XM_005248612.4XP_005248669.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
      Conserved Domains (1) summary
      pfam03987
      Location:64131
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    5. XM_047417798.1XP_047273754.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    6. XM_047417802.1XP_047273758.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    7. XM_005248611.6XP_005248668.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      See identical proteins and their annotated locations for XP_005248668.1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
      Conserved Domains (1) summary
      pfam03987
      Location:100167
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    8. XM_047417799.1XP_047273755.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
      Related
      ENSP00000425225.1, ENST00000513634.1
    9. XM_005248610.6XP_005248667.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      See identical proteins and their annotated locations for XP_005248667.1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
      Conserved Domains (1) summary
      pfam03987
      Location:100167
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    10. XM_047417801.1XP_047273757.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    11. XM_011543660.3XP_011541962.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

      Conserved Domains (1) summary
      pfam03987
      Location:58125
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    12. XM_011543661.3XP_011541963.1  ubiquitin-like-conjugating enzyme ATG10 isoform X4

      Conserved Domains (1) summary
      pfam03987
      Location:3097
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      82456197..82741920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353610.1XP_054209585.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    2. XM_054353615.1XP_054209590.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    3. XM_054353612.1XP_054209587.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    4. XM_054353611.1XP_054209586.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    5. XM_054353606.1XP_054209581.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    6. XM_054353614.1XP_054209589.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    7. XM_054353608.1XP_054209583.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    8. XM_054353609.1XP_054209584.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    9. XM_054353607.1XP_054209582.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      UniProtKB/Swiss-Prot
      B2RE09, Q6PIX1, Q9H0Y0, Q9H842
      UniProtKB/TrEMBL
      D6RDX3
    10. XM_054353613.1XP_054209588.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      D6RDX3
    11. XM_054353616.1XP_054209591.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

    12. XM_054353617.1XP_054209592.1  ubiquitin-like-conjugating enzyme ATG10 isoform X4