CCN3 cellular communication network factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCN3provided by HGNC
Official Full Name: cellular communication network factor 3provided by HGNC
Primary source: HGNC:HGNC:7885
See related: Ensembl:ENSG00000136999 MIM:164958; AllianceGenome:HGNC:7885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NOV; NOVh; IBP-9; IGFBP9; IGFBP-9
Summary: The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
Expression: Biased expression in adrenal (RPKM 648.6) and prostate (RPKM 11.0) See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (119416446..119424434)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (120544918..120552906)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (120428686..120436674)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A maternal brain hormone that builds bone.
Title: A maternal brain hormone that builds bone.
CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer.
Title: CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer.
Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing.
Title: Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing.
NOV/CCN3 Promotes Cell Migration and Invasion in Intrahepatic Cholangiocarcinoma via miR-92a-3p.
Title: NOV/CCN3 Promotes Cell Migration and Invasion in Intrahepatic Cholangiocarcinoma via miR-92a-3p.
CCN3 Proteins as a diagnostic marker in osteosarcoma patients: A case control study.
Title: CCN3 Proteins as a diagnostic marker in osteosarcoma patients: A case control study.
RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.
Title: RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Title: CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Dysregulation of CCN3 (NOV) expression in the epidermis of systemic sclerosis patients with pigmentary changes.
Title: Dysregulation of CCN3 (NOV) expression in the epidermis of systemic sclerosis patients with pigmentary changes.
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.
Title: SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.
CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.
Title: CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in bone regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in type B pancreatic cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCN family member 3

Names: IGF-binding protein 9; insulin-like growth factor-binding protein 9; nephro blastoma-overexpressed gene protein homolog; nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; protein NOV homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009779.1 RefSeqGene

Range

5135..13123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002514.4 → NP_002505.1 CCN family member 3 precursor

See identical proteins and their annotated locations for NP_002505.1

Status: REVIEWED

Source sequence(s)

AC021733, AY082381, DA162276

Consensus CDS

CCDS6328.1

UniProtKB/Swiss-Prot

B2R5X7, P48745, Q6I9S3, Q96BY5, Q9UDE4

UniProtKB/TrEMBL

B4DFW1

Related

ENSP00000259526.3, ENST00000259526.4

Conserved Domains (3) summary

smart00121
Location:33 → 95

IB; Insulin growth factor-binding protein homologues

smart00041
Location:269 → 338

CT; C-terminal cystine knot-like domain (CTCK)

smart00214
Location:110 → 170

VWC; von Willebrand factor (vWF) type C domain