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    GPBP1L1 GC-rich promoter binding protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 60313, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPBP1L1provided by HGNC
    Official Full Name
    GC-rich promoter binding protein 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28843
    See related
    Ensembl:ENSG00000159592 AllianceGenome:HGNC:28843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SP192
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 44.4), thyroid (RPKM 35.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPBP1L1 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45627304..45688110, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45499652..45560916, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46092976..46152205, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054000-46054500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054501-46055001 Neighboring gene MPRA-validated peak199 silencer Neighboring gene nuclear autoantigenic sperm protein Neighboring gene coiled-coil domain containing 17 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
    2. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
    3. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article
    4. Proximity labeling reveals dynamic changes in the SQSTM1 protein network. Rondón-Ortiz AN, et al. J Biol Chem, 2024 Sep. PMID 39098523, Free PMC Article
    5. Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Lü Y, et al. Mol Syst Biol, 2024 Jun. PMID 38580884, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vasculin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021639.5 → NP_067652.1  vasculin-like protein 1

      See identical proteins and their annotated locations for NP_067652.1

      Status: VALIDATED

      Source sequence(s)
      BC022218, BC068578, BU627076
      Consensus CDS
      CCDS528.1
      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Related
      ENSP00000347224.3, ENST00000355105.8
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45627304..45688110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427077.1 → XP_047283033.1  vasculin-like protein 1 isoform X2

    2. XM_024448810.2 → XP_024304578.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    3. XM_047427059.1 → XP_047283015.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    4. XM_047427066.1 → XP_047283022.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    5. XM_047427070.1 → XP_047283026.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    6. XM_047427067.1 → XP_047283023.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    7. XM_047427069.1 → XP_047283025.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    8. XM_024448808.2 → XP_024304576.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    9. XM_047427075.1 → XP_047283031.1  vasculin-like protein 1 isoform X2

    10. XM_024448806.2 → XP_024304574.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    11. XM_047427076.1 → XP_047283032.1  vasculin-like protein 1 isoform X2

    12. XM_024448809.2 → XP_024304577.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Related
      ENSP00000290795.3, ENST00000290795.7
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    13. XM_017002019.3 → XP_016857508.1  vasculin-like protein 1 isoform X2

    14. XM_047427078.1 → XP_047283034.1  vasculin-like protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45499652..45560916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338058.1 → XP_054194033.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    2. XM_054338057.1 → XP_054194032.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    3. XM_054338066.1 → XP_054194041.1  vasculin-like protein 1 isoform X2

    4. XM_054338059.1 → XP_054194034.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    5. XM_054338055.1 → XP_054194030.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    6. XM_054338056.1 → XP_054194031.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    7. XM_054338060.1 → XP_054194035.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    8. XM_054338061.1 → XP_054194036.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    9. XM_054338064.1 → XP_054194039.1  vasculin-like protein 1 isoform X2

    10. XM_054338062.1 → XP_054194037.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    11. XM_054338065.1 → XP_054194040.1  vasculin-like protein 1 isoform X2

    12. XM_054338054.1 → XP_054194029.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    13. XM_054338063.1 → XP_054194038.1  vasculin-like protein 1 isoform X2

    14. XM_054338067.1 → XP_054194042.1  vasculin-like protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HC44.1 GenPept UniProtKB/Swiss-Prot:Q9HC44

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