ZNF224 zinc finger protein 224 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF224provided by HGNC
Official Full Name: zinc finger protein 224provided by HGNC
Primary source: HGNC:HGNC:13017
See related: Ensembl:ENSG00000267680 MIM:194555; AllianceGenome:HGNC:13017
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BMZF2; KOX22; ZNF27; BMZF-2; ZNF233; ZNF255
Summary: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Expression: Ubiquitous expression in spleen (RPKM 8.7), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (44094361..44109826)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (46917263..46932721)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (44598514..44613979)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF224 is a mediator of TGF-beta pro-oncogenic function in melanoma.
Title: ZNF224 is a mediator of TGF-β pro-oncogenic function in melanoma.
ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
Title: ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity.
Title: ZNF224 is a transcriptional repressor of AXL in chronic myeloid leukemia cells.
The analyses using human breast ductal carcinoma tissues exhibited that the expression of ZNF224 and miR-663a was increased in cancer compared to non-cancer region.
Title: ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a.
we showed that ZNF224 positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
Title: Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia.
Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer
Title: The Complex Role of the ZNF224 Transcription Factor in Cancer.
Data show that Wilms' tumor 1 protein (WT1)binds to the zinc finger protein 224 (ZNF224) promoter and represses ZNF224 expression.
Title: WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.
ZNF224 acts in fine tuning of WT1-dependent control of gene expression, acting as a co-activator of WT1 in the regulation of proapoptotic genes and suppressing WT1 mediated transactivation of antiapoptotitc genes.
Title: Role of WT1-ZNF224 interaction in the expression of apoptosis-regulating genes.
REVIEW: ZNF224 is a multifunctional protein and alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity
Title: ZNF224: Structure and role of a multifunctional KRAB-ZFP protein.
ZNF224 acts as a transcriptional co-regulator of WT1.
Title: Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43534 (e-PCR)
- UniSTS:94991

RH120072 (e-PCR)
- UniSTS:133395

D19S701E (e-PCR)
- UniSTS:150601

D15S1477 (e-PCR)
- UniSTS:474482

WI-21930 (e-PCR)
- UniSTS:62891

RH79753 (e-PCR)
- UniSTS:92597

L29953 (e-PCR)
- UniSTS:52164

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 224

Names: bone marrow zinc finger 2; zinc finger protein 233; zinc finger protein 255; zinc finger protein 27; zinc finger protein KOX22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051221.1 RefSeqGene

Range

5033..20498

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001321645.3 → NP_001308574.1 zinc finger protein 224

Status: REVIEWED

Source sequence(s)

AA554187, AC021092, AC114266, CN304667, DA245440, DB228337

Consensus CDS

CCDS33046.1

UniProtKB/Swiss-Prot

A6NFW9, P17033, Q86V10, Q8IZC8, Q9NZL3, Q9UID9, Q9Y2P6

Related

ENSP00000508532.1, ENST00000693561.1

Conserved Domains (3) summary

smart00349
Location:8 → 67

KRAB; krueppel associated box

COG5048
Location:202 → 641

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:542 → 562

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_013398.5 → NP_037530.2 zinc finger protein 224

See identical proteins and their annotated locations for NP_037530.2

Status: REVIEWED

Source sequence(s)

AA554187, AC021092, AC114266, BC051902, DA245440

Consensus CDS

CCDS33046.1

UniProtKB/Swiss-Prot

A6NFW9, P17033, Q86V10, Q8IZC8, Q9NZL3, Q9UID9, Q9Y2P6

Related

ENSP00000337368.5, ENST00000336976.10

Conserved Domains (3) summary

smart00349
Location:8 → 67

KRAB; krueppel associated box

COG5048
Location:202 → 641

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:542 → 562

ZF_C2H2; C2H2 Zn finger [structural motif]