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    NCLN nicalin [ Homo sapiens (human) ]

    Gene ID: 56926, updated on 27-Nov-2024

    Summary

    Official Symbol
    NCLNprovided by HGNC
    Official Full Name
    nicalinprovided by HGNC
    Primary source
    HGNC:HGNC:26923
    See related
    Ensembl:ENSG00000125912 MIM:609156; AllianceGenome:HGNC:26923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET59
    Summary
    Enables ribosome binding activity. Involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NCLN in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3185930..3209575)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3160750..3184441)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3185928..3209573)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3141544-3142044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3154789-3155746 Neighboring gene GNA15 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 13242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3163409-3164269 Neighboring gene G protein subunit alpha 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3176749-3177631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:3185006-3185888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3189343-3189846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3189847-3190350 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3227850-3228390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3228391-3228930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3229472-3230011 Neighboring gene CUGBP Elav-like family member 5 Neighboring gene MPRA-validated peak3244 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9835 Neighboring gene uncharacterized LOC105372244 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3301113-3301307 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13733 Neighboring gene skeletal muscle cis-regulatory module in NFIC intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3389688-3390265 Neighboring gene nuclear factor I C Neighboring gene Sharpr-MPRA regulatory region 10296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3434103-3434880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3434881-3435658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3445307-3445848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3462537-3463072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3463073-3463608 Neighboring gene MPRA-validated peak3246 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3465190-3465690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3465691-3466191 Neighboring gene Sharpr-MPRA regulatory region 13615

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    BOS complex subunit NCLN
    Names
    nicalin homolog
    nicastrin-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321463.2NP_001308392.1  BOS complex subunit NCLN isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011547, BC025926, BG420915, BU508470, GD158011
      UniProtKB/TrEMBL
      B2RA56
      Conserved Domains (1) summary
      cd03882
      Location:130429
      M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
    2. NM_020170.4NP_064555.2  BOS complex subunit NCLN isoform 1 precursor

      See identical proteins and their annotated locations for NP_064555.2

      Status: VALIDATED

      Source sequence(s)
      AL136567, AL365369, BC003076, BC007275, BC008920, BC010064, BC013283, BC025926
      Consensus CDS
      CCDS32869.1
      UniProtKB/Swiss-Prot
      D6W613, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q969V3, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2
      UniProtKB/TrEMBL
      B2RA56
      Related
      ENSP00000246117.3, ENST00000246117.9
      Conserved Domains (1) summary
      cd03882
      Location:127429
      M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      3185930..3209575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      3160750..3184441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)