TRERNA1 translation regulatory long non-coding RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRERNA1provided by HGNC
Official Full Name: translation regulatory long non-coding RNA 1provided by HGNC
Primary source: HGNC:HGNC:44307
See related: AllianceGenome:HGNC:44307
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEF; treRNA; LINC00651
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 20q13.13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (50040707..50041629, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (51810325..51811247, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (48657244..48658166, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer.
Title: Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer.
SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis.
Title: SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis.
Elevated LncRNA TRERNA1 correlated with activation of HIF-1alpha predicts poor prognosis in hepatocellular carcinoma.
Title: Elevated LncRNA TRERNA1 correlated with activation of HIF-1α predicts poor prognosis in hepatocellular carcinoma.
Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure.
Title: Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure.
Expression and Clinical Significance of Translation Regulatory Long Non-Coding RNA 1 (TRERNA1) in Ependymomas.
Title: Expression and Clinical Significance of Translation Regulatory Long Non-Coding RNA 1 (TRERNA1) in Ependymomas.
LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1.
Title: LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1.
TRERNA1 promotes cell metastasis and the invasion of HCC via the recruitment of EHMT2 and/or the EHMT2/SNAI1 complex to suppress CDH1.
Title: LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex.
TFAP4 can directly modulate the expression of TRERNA1.
Title: Elevated TFAP4 regulates lncRNA TRERNA1 to promote cell migration and invasion in gastric cancer.
we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage.
Title: The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.
Data suggest that suppression of treRNA (translation regulatory long non-coding RNA) by microRNA-190a leads to down-regulation of mesenchymal-epithelial transition and of cell migration/neoplastic invasiveness of hepatoma cells.
Title: miR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Other Names

c-Myc Enhancing Factor
long intergenic non-protein coding RNA 651
ncRNA-a7
noncoding RNA-activating 7
translational regulatory long non-coding RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.