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    STK32A serine/threonine kinase 32A [ Homo sapiens (human) ]

    Gene ID: 202374, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STK32Aprovided by HGNC
    Official Full Name
    serine/threonine kinase 32Aprovided by HGNC
    Primary source
    HGNC:HGNC:28317
    See related
    Ensembl:ENSG00000169302 AllianceGenome:HGNC:28317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YANK1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal (RPKM 5.1), thyroid (RPKM 4.8) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK32A in Genome Data Viewer
    Location:
    5q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (147235026..147401990)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147770995..147937774)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146614589..146767418)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23362 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:146473503-146474702 Neighboring gene STK32A antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81891 Neighboring gene NANOG hESC enhancer GRCh37_chr5:146835510-146836011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16489 Neighboring gene dihydropyrimidinase like 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:146935385-146935884 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146940356-146941285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146946379-146947278 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146947279-146948178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146948179-146949078 Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:147051411-147052610 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147101014-147101804 Neighboring gene uncharacterized LOC105378218

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer. Ma F, et al. BMC Cancer, 2020 Jun 22. PMID 32571328, Free PMC Article
    2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. Koskinen LL, et al. Tissue Antigens, 2009 Nov. PMID 19845895
    3. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
    4. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
    5. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer.
      Title: The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC22688

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 32A
    Names
    A930015B13Rik
    CTB-108O6.2
    yet another novel kinase 1
    NP_001106195.1
    NP_001274669.1
    NP_659438.1
    XP_011535878.1
    XP_011535879.1
    XP_011535881.1
    XP_016864702.1
    XP_016864703.1
    XP_047272868.1
    XP_054207986.1
    XP_054207987.1
    XP_054207988.1
    XP_054207989.1
    XP_054207990.1
    XP_054207991.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112724.2 → NP_001106195.1  serine/threonine-protein kinase 32A isoform 1

      See identical proteins and their annotated locations for NP_001106195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC009189, BC021666, DA110948, DA231845, DR006392, EB386256
      Consensus CDS
      CCDS47299.1
      UniProtKB/Swiss-Prot
      B3KSY0, Q8WU08
      UniProtKB/TrEMBL
      B4DR46
      Related
      ENSP00000381030.3, ENST00000397936.8
      Conserved Domains (2) summary
      smart00220
      Location:23 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22 → 281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    2. NM_001287740.2 → NP_001274669.1  serine/threonine-protein kinase 32A isoform 3

      See identical proteins and their annotated locations for NP_001274669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC009189, AK315942
      Consensus CDS
      CCDS75351.1
      UniProtKB/TrEMBL
      B4DR46, B7Z9H7
      Related
      ENSP00000381535.3, ENST00000398523.3
      Conserved Domains (1) summary
      cd05578
      Location:22 → 281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    3. NM_145001.4 → NP_659438.1  serine/threonine-protein kinase 32A isoform 2

      See identical proteins and their annotated locations for NP_659438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC009189, AC011338
      Consensus CDS
      CCDS54931.1
      UniProtKB/Swiss-Prot
      Q8WU08
      Related
      ENSP00000487441.1, ENST00000626951.2
      Conserved Domains (1) summary
      cl21453
      Location:22 → 157
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      147235026..147401990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537577.3 → XP_011535879.1  serine/threonine-protein kinase 32A isoform X2

      UniProtKB/TrEMBL
      B4DR46
      Conserved Domains (2) summary
      smart00220
      Location:23 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22 → 281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    2. XM_017009213.2 → XP_016864702.1  serine/threonine-protein kinase 32A isoform X3

      UniProtKB/TrEMBL
      A0A3B3IS85
      Related
      ENSP00000497167.1, ENST00000648628.1

    3. XM_011537579.3 → XP_011535881.1  serine/threonine-protein kinase 32A isoform X5

      See identical proteins and their annotated locations for XP_011535881.1

      Conserved Domains (2) summary
      smart00220
      Location:23 → 220
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22 → 221
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    4. XM_047416912.1 → XP_047272868.1  serine/threonine-protein kinase 32A isoform X5

    5. XM_011537576.1 → XP_011535878.1  serine/threonine-protein kinase 32A isoform X1

      UniProtKB/TrEMBL
      B4DR46
      Conserved Domains (2) summary
      smart00220
      Location:21 → 268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:20 → 279
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    6. XM_017009214.1 → XP_016864703.1  serine/threonine-protein kinase 32A isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      147770995..147937774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352012.1 → XP_054207987.1  serine/threonine-protein kinase 32A isoform X2

    2. XM_054352013.1 → XP_054207988.1  serine/threonine-protein kinase 32A isoform X3

    3. XM_054352015.1 → XP_054207990.1  serine/threonine-protein kinase 32A isoform X5

    4. XM_054352016.1 → XP_054207991.1  serine/threonine-protein kinase 32A isoform X5

    5. XM_054352011.1 → XP_054207986.1  serine/threonine-protein kinase 32A isoform X1

    6. XM_054352014.1 → XP_054207989.1  serine/threonine-protein kinase 32A isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WU08.2 GenPept UniProtKB/Swiss-Prot:Q8WU08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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