FBXO17 F-box protein 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXO17provided by HGNC
Official Full Name: F-box protein 17provided by HGNC
Primary source: HGNC:HGNC:18754
See related: Ensembl:ENSG00000269190 MIM:609094; AllianceGenome:HGNC:18754
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FBG4; FBX26; Fbx17; FBXO26
Summary: This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Broad expression in kidney (RPKM 11.1), ovary (RPKM 9.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38941401..38975742, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41745371..41779692, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39432041..39466382, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR-217.
Title: Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR-217.
FBXO17 Inhibits the Wnt/beta-Catenin Pathway and Proliferation of Ishikawa Cells.
Title: FBXO17 Inhibits the Wnt/β-Catenin Pathway and Proliferation of Ishikawa Cells.
F-box protein 17 promotes glioma progression by regulating glycolysis pathway.
Title: F-box protein 17 promotes glioma progression by regulating glycolysis pathway.
Identification and validation of an immune-associated RNA-binding proteins signature to predict clinical outcomes and therapeutic responses in colon cancer patients.
Title: Identification and validation of an immune-associated RNA-binding proteins signature to predict clinical outcomes and therapeutic responses in colon cancer patients.
FBXO17 promotes malignant progression of hepatocellular carcinoma by activating wnt/beta-catenin pathway.
Title: FBXO17 promotes malignant progression of hepatocellular carcinoma by activating wnt/β-catenin pathway.
These data support a role for FBXO17 overexpression in regulating cell proliferation and survival through modulation of Akt and ERK kinase activation and a potential role for the F-box subunit in modulating tumorigenesis in lung cancers.
Title: FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells.
Studied expression levels of F-box protein 17 (FBX017) in high grade gliomas; found patients with higher FBXO17 expression had a shorter overall survival.
Title: Clinical significance of FBXO17 gene expression in high-grade glioma.
our studies identify a previously unreported role of FBXO17 in regulating IFN-I signaling
Title: A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation.
identified FBXO17 as an F-box protein subunit that recognizes and mediates GSK3beta polyubiquitination.
Title: SCF(FBXO17) E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3β in lung epithelia.
the apparent occurrence of an unusual TG 3' splice site in intron 3 is discussed
Title: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: F-box only protein 17

Names: F-box only protein 26; F-box protein FBG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050566.1 RefSeqGene

Range

5072..39413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_024907.7 → NP_079183.4 F-box only protein 17 isoform 2

See identical proteins and their annotated locations for NP_079183.4

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the shorter isoform (2).

Source sequence(s)

AF386743, AI050825, BM711851, CA429117, CF594009

Consensus CDS

CCDS12526.1

UniProtKB/Swiss-Prot

Q96EF6, Q96LQ4

Related

ENSP00000292852.3, ENST00000292852.9

Conserved Domains (2) summary

pfam04300
Location:100 → 271

FBA; F-box associated region

pfam12937
Location:18 → 59

F-box-like
NM_148169.3 → NP_680474.1 F-box only protein 17 isoform 1

See identical proteins and their annotated locations for NP_680474.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 2. It encodes isoform 1, which has a longer N-terminus, compared to isoform 2.

Source sequence(s)

AF386743, AI050825, AK057934, BM711851, CA429117

UniProtKB/Swiss-Prot

Q96EF6

Conserved Domains (2) summary

pfam04300
Location:110 → 282

FBA; F-box associated region

pfam12937
Location:27 → 68

F-box-like; F-box-like

RNA

NR_104026.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF386743, AI050825, BM711851, BX338290, CA429117, CF594009