RERG RAS like estrogen regulated growth inhibitor [Homo sapiens (human)] - Gene

Summary

Official Symbol: RERGprovided by HGNC
Official Full Name: RAS like estrogen regulated growth inhibitorprovided by HGNC
Primary source: HGNC:HGNC:15980
See related: Ensembl:ENSG00000134533 MIM:612664; AllianceGenome:HGNC:15980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
Expression: Broad expression in endometrium (RPKM 41.3), adrenal (RPKM 21.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p12.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (15107783..15221417, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (14985067..15098688, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (15260717..15374351, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NF-kappaB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-kappaB pathways by targeting RERG in glioma cells.
Title: NF-κB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-κB pathways by targeting RERG in glioma cells.
Study revealed that ERK5 can inhibit Raslike oestrogenregulated growth inhibitor (RERG) protein expression and that the inhibition of RERG expression promotes prostatic carcinoma cell proliferation and migration.
Title: ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma.
In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes.
Title: Quantitation of DNA methylation in Epstein-Barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing.
this study shows that miR-382-5p expression is negatively correlated with RERG expression, and functions as an independent oncomiR for the higher incidence and poorer prognosis of breast cancer
Title: MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
Estradiol estrogen receptor-beta and PGE2 integrate at RERG, leading to increased endometriotic cell proliferation.
Title: ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis.
Results describe the mRNA expression of CRABP1, RERG, and GRP in pituitary adenomas.
Title: Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas.
Loss of RERG expression is associated with breast cancer and distant metastasis.
Title: RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62340 (e-PCR)
- UniSTS:139288

D12S62 (e-PCR)
- UniSTS:18990

SHGC-145192 (e-PCR)
- UniSTS:174436

A004W33 (e-PCR)
- UniSTS:60265

RH118683 (e-PCR)
- UniSTS:138180

Bda17c02 (e-PCR)
- UniSTS:55277

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	TAS Traceable Author Statement more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related and estrogen-regulated growth inhibitor

NP_001177655.1

EC 3.6.5.2

NP_116307.1

EC 3.6.5.2

XP_047285753.1

EC 3.6.5.2

XP_047285754.1

EC 3.6.5.2

XP_054229660.1

EC 3.6.5.2

XP_054229661.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190726.2 → NP_001177655.1 ras-related and estrogen-regulated growth inhibitor isoform 2

See identical proteins and their annotated locations for NP_001177655.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK295343, BC007997

Consensus CDS

CCDS53753.1

UniProtKB/Swiss-Prot

Q96A58

Related

ENSP00000444485.1, ENST00000546331.5

Conserved Domains (1) summary

cl38936
Location:8 → 150

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_032918.3 → NP_116307.1 ras-related and estrogen-regulated growth inhibitor isoform 1

See identical proteins and their annotated locations for NP_116307.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC007997, DC331754

Consensus CDS

CCDS8673.1

UniProtKB/Swiss-Prot

B2R9R0, B4DI02, Q96A58

Related

ENSP00000256953.2, ENST00000256953.6

Conserved Domains (1) summary

cd04146
Location:8 → 169

RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

15107783..15221417 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429797.1 → XP_047285753.1 ras-related and estrogen-regulated growth inhibitor isoform X1
XM_047429798.1 → XP_047285754.1 ras-related and estrogen-regulated growth inhibitor isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

14985067..15098688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054373685.1 → XP_054229660.1 ras-related and estrogen-regulated growth inhibitor isoform X1
XM_054373686.1 → XP_054229661.1 ras-related and estrogen-regulated growth inhibitor isoform X2