RGS10 regulator of G protein signaling 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS10provided by HGNC
Official Full Name: regulator of G protein signaling 10provided by HGNC
Primary source: HGNC:HGNC:9992
See related: Ensembl:ENSG00000148908 MIM:602856; AllianceGenome:HGNC:9992
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 32.4), appendix (RPKM 20.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (119499817..119542719, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (120395411..120438320, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (121259329..121302231, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic insights into Familial Mediterranean Fever: Increased RGS10 expression and histone modifications accompanies inflammation in familial Mediterranean fever disease.
Title: Epigenetic insights into Familial Mediterranean Fever: Increased RGS10 expression and histone modifications accompanies inflammation in familial Mediterranean fever disease.
RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma.
Title: RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma.
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Title: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Short stature and combined immunodeficiency associated with mutations in RGS10.
Title: Short stature and combined immunodeficiency associated with mutations in RGS10.
Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.
Title: Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.
A broad analysis in clinical and in vitro models on regulator of G-protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance.
Title: A broad analysis in clinical and in vitro models on regulator of G-protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance.
RGS10 inhibits COX-2 expression.
Title: RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism.
RGS10 plays a role in chemoresistance in ovarian cancer. Loss of RGS10 enhances survival among these cells.
Title: Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
RGS10 could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP from Rheb in ovarian cancer cells.
Title: Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
Title: Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-33199 (e-PCR)
- UniSTS:43603

WI-15787 (e-PCR)
- UniSTS:44920

SHGC-142529 (e-PCR)
- UniSTS:171512

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 10

Names: regulator of G-protein signalling 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005339.2 → NP_001005339.1 regulator of G-protein signaling 10 isoform a

See identical proteins and their annotated locations for NP_001005339.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC012468, AI219612, AL355273, AL547312, BC009361, BF685740, BG763741, BM782346, BM914660, CB112318, CB124184

Consensus CDS

CCDS31294.1

UniProtKB/Swiss-Prot

A8K408, B1AMR8, O43665, Q6IAZ6, Q96GN0

Related

ENSP00000358099.2, ENST00000369103.3

Conserved Domains (1) summary

cd08741
Location:42 → 154

RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein
NM_002925.4 → NP_002916.1 regulator of G-protein signaling 10 isoform b

See identical proteins and their annotated locations for NP_002916.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AI219612, AL355273, AL592286, AV707839, BC009361, BF685740, BM914660

Consensus CDS

CCDS41572.1

UniProtKB/Swiss-Prot

O43665

Related

ENSP00000376605.1, ENST00000392865.5

Conserved Domains (1) summary

cd08741
Location:28 → 140

RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein