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    DGKB diacylglycerol kinase beta [ Homo sapiens (human) ]

    Gene ID: 1607, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DGKBprovided by HGNC
    Official Full Name
    diacylglycerol kinase betaprovided by HGNC
    Primary source
    HGNC:HGNC:2850
    See related
    Ensembl:ENSG00000136267 MIM:604070; AllianceGenome:HGNC:2850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DGK; DAGK2; DGK-BETA
    Summary
    Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
    Expression
    Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DGKB in Genome Data Viewer
    Location:
    7p21.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (14145049..14974858, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (14277079..15107587, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (14184674..15014483, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 2 pseudogene Neighboring gene uncharacterized LOC105375162 Neighboring gene NANOG hESC enhancer GRCh37_chr7:14104855-14105356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:14119884-14121083 Neighboring gene MPRA-validated peak6403 silencer Neighboring gene ribosomal protein L6 pseudogene 21 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:14308715-14309214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:14308213-14308714 Neighboring gene MPRA-validated peak6405 silencer Neighboring gene VISTA enhancer hs816 Neighboring gene uncharacterized LOC105375164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:14779612-14780128 Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene uncharacterized LOC124901592 Neighboring gene alkylglycerol monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diacylglycerol kinases: at the hub of cell signalling. Mérida I, et al. Biochem J, 2008 Jan 1. PMID 18062770
    2. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. Kano T, et al. Biochem Biophys Res Commun, 2014 Apr 25. PMID 24695318
    3. DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma. Kang H, et al. Cell Rep Med, 2023 Jan 17. PMID 36603576, Free PMC Article
    4. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Goto K, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 7689223, Free PMC Article
    5. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. Caricasole A, et al. J Biol Chem, 2002 Feb 15. PMID 11719522

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKbeta-Induced Neurite Outgrowth.
      Title: RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth.
    2. DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.
      Title: DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.
    3. RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output.
      Title: Discovering human diabetes-risk gene function with genetics and physiological assays.
    4. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood.
      Title: Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization.
    5. in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta
      Title: Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ.
    6. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst.
      Title: Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.
    7. findings further suggest that DGL-alpha and -beta may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways
      Title: Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms.
    8. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
    EBI GWAS Catalog
    Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
    EBI GWAS Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase beta
    Names
    90 kDa diacylglycerol kinase
    DAG kinase beta
    diacylglycerol kinase, beta 90kDa
    diglyceride kinase beta
    NP_001337634.1
    NP_001337635.1
    NP_001337636.1
    NP_001337637.1
    NP_001337638.1
    NP_001337640.1
    NP_001337641.1
    NP_001337643.1
    NP_001337644.1
    NP_001337645.1
    NP_001337646.1
    NP_001337647.1
    NP_001337648.1
    NP_001337649.1
    NP_001337650.1
    NP_001337651.1
    NP_001337652.1
    NP_001337653.1
    NP_663733.1
    XP_011513456.1
    XP_016867279.1
    XP_016867280.1
    XP_016867281.1
    XP_047275885.1
    XP_047275886.1
    XP_054213340.1
    XP_054213341.1
    XP_054213342.1
    XP_054213343.1
    XP_054213344.1
    XP_054213345.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029494.2 RefSeqGene

      Range
      77027..834729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350705.1 → NP_001337634.1  diacylglycerol kinase beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS47547.1
      UniProtKB/Swiss-Prot
      A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
      UniProtKB/TrEMBL
      B7Z9A9
      Related
      ENSP00000385780.2, ENST00000403951.6
      Conserved Domains (6) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. NM_001350706.2 → NP_001337635.1  diacylglycerol kinase beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS47547.1
      UniProtKB/Swiss-Prot
      A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
      UniProtKB/TrEMBL
      B7Z9A9
      Related
      ENSP00000382260.3, ENST00000399322.7
      Conserved Domains (6) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. NM_001350707.2 → NP_001337636.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87481.1
      UniProtKB/TrEMBL
      B5MBY2, B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. NM_001350708.1 → NP_001337637.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87481.1
      UniProtKB/TrEMBL
      B5MBY2, B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    5. NM_001350709.2 → NP_001337638.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87481.1
      UniProtKB/TrEMBL
      B5MBY2, B7Z9A9
      Related
      ENSP00000384909.1, ENST00000402815.6
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    6. NM_001350711.2 → NP_001337640.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87480.1
      UniProtKB/TrEMBL
      B5MCD5, B5MDK1, B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    7. NM_001350712.1 → NP_001337641.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87480.1
      UniProtKB/TrEMBL
      B5MCD5, B5MDK1, B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    8. NM_001350714.2 → NP_001337643.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS87480.1
      UniProtKB/TrEMBL
      B5MCD5, B5MDK1, B7Z9A9
      Related
      ENSP00000385031.1, ENST00000407950.5
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    9. NM_001350715.1 → NP_001337644.1  diacylglycerol kinase beta isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:575 → 755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433 → 554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    10. NM_001350716.2 → NP_001337645.1  diacylglycerol kinase beta isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:575 → 755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433 → 554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    11. NM_001350717.2 → NP_001337646.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:570 → 750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    12. NM_001350718.1 → NP_001337647.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:570 → 750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    13. NM_001350719.2 → NP_001337648.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:570 → 750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    14. NM_001350720.1 → NP_001337649.1  diacylglycerol kinase beta isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 7.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:563 → 743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    15. NM_001350721.2 → NP_001337650.1  diacylglycerol kinase beta isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 7.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:563 → 743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 352
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    16. NM_001350722.2 → NP_001337651.1  diacylglycerol kinase beta isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform 8.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:540 → 720
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:398 → 519
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:203 → 252
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:111 → 180
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:268 → 317
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:14 → 107
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    17. NM_001350723.2 → NP_001337652.1  diacylglycerol kinase beta isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform 8.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:540 → 720
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:398 → 519
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:203 → 252
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:111 → 180
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:268 → 317
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:14 → 107
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    18. NM_001350724.2 → NP_001337653.1  diacylglycerol kinase beta isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) encodes isoform 9.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:532 → 712
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390 → 511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:196 → 245
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:104 → 173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:261 → 310
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 100
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    19. NM_145695.2 → NP_663733.1  diacylglycerol kinase beta isoform 2

      See identical proteins and their annotated locations for NP_663733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 3' UTR and 3' coding region compared to variant (1). The encoded protein (2) has a shorter, alternate C-terminus compared to isoform (1).
      Source sequence(s)
      AC005039, BC105005, DA321150
      Consensus CDS
      CCDS47548.1
      UniProtKB/TrEMBL
      B7ZL83
      Related
      ENSP00000386066.3, ENST00000406247.7
      Conserved Domains (6) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      14145049..14974858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515154.3 → XP_011513456.1  diacylglycerol kinase beta isoform X1

      See identical proteins and their annotated locations for XP_011513456.1

      UniProtKB/Swiss-Prot
      A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7
      UniProtKB/TrEMBL
      B7Z9A9
      Conserved Domains (6) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 359
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_047419929.1 → XP_047275885.1  diacylglycerol kinase beta isoform X3

    3. XM_017011790.2 → XP_016867279.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      B7ZL83
      Conserved Domains (7) summary
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:154 → 218
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl02440
      Location:582 → 679
      DAGK_acc; Diacylglycerol kinase accessory domain

    4. XM_017011791.2 → XP_016867280.1  diacylglycerol kinase beta isoform X4

    5. XM_047419930.1 → XP_047275886.1  diacylglycerol kinase beta isoform X6

    6. XM_017011792.3 → XP_016867281.1  diacylglycerol kinase beta isoform X5

    RNA

    1. XR_001744571.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      14277079..15107587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357365.1 → XP_054213340.1  diacylglycerol kinase beta isoform X1

      UniProtKB/Swiss-Prot
      A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29, Q9Y6T7

    2. XM_054357367.1 → XP_054213342.1  diacylglycerol kinase beta isoform X3

    3. XM_054357366.1 → XP_054213341.1  diacylglycerol kinase beta isoform X2

    4. XM_054357368.1 → XP_054213343.1  diacylglycerol kinase beta isoform X4

    5. XM_054357370.1 → XP_054213345.1  diacylglycerol kinase beta isoform X6

    6. XM_054357369.1 → XP_054213344.1  diacylglycerol kinase beta isoform X5

    RNA

    1. XR_008487537.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004080.2: Suppressed sequence

      Description
      NM_004080.2: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6T7.2 GenPept UniProtKB/Swiss-Prot:Q9Y6T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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