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    PAPOLB poly(A) polymerase beta [ Homo sapiens (human) ]

    Gene ID: 56903, updated on 9-Dec-2024

    Summary

    Official Symbol
    PAPOLBprovided by HGNC
    Official Full Name
    poly(A) polymerase betaprovided by HGNC
    Primary source
    HGNC:HGNC:15970
    See related
    Ensembl:ENSG00000218823 MIM:607436; AllianceGenome:HGNC:15970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPT; TPAP
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See PAPOLB in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4857738..4862030, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4974940..4979232, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4897369..4901661, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4832559-4833233 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17904 Neighboring gene microRNA 4656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4847903-4848404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4848405-4848904 Neighboring gene Rap associating with DIL domain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4878225-4878893 Neighboring gene small nucleolar RNA, C/D box 165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4900904-4901516 Neighboring gene ribosomal protein L22 pseudogene 16 Neighboring gene Sharpr-MPRA regulatory region 4159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4922762-4923449 Neighboring gene monocyte to macrophage differentiation associated 2

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    poly(A) polymerase beta
    Names
    PAP-beta
    poly(A) polymerase beta (testis specific)
    polynucleotide adenylyltransferase beta
    testis-specific poly(A) polymerase
    NP_064529.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020144.5NP_064529.4  poly(A) polymerase beta

      See identical proteins and their annotated locations for NP_064529.4

      Status: VALIDATED

      Source sequence(s)
      AC092610, AF218840, BC036653
      Consensus CDS
      CCDS78202.1
      UniProtKB/Swiss-Prot
      Q75LH1, Q8NE14, Q9NRJ5
      UniProtKB/TrEMBL
      A0ZTA0, A4D1Z6
      Related
      ENSP00000384700.2, ENST00000404991.2
      Conserved Domains (3) summary
      PTZ00418
      Location:21569
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:367496
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:22364
      PAP_central; Poly(A) polymerase central domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      4857738..4862030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      4974940..4979232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)