OMA1 OMA1 zinc metallopeptidase [Homo sapiens (human)] - Gene

Summary

Official Symbol: OMA1provided by HGNC
Official Full Name: OMA1 zinc metallopeptidaseprovided by HGNC
Primary source: HGNC:HGNC:29661
See related: Ensembl:ENSG00000162600 MIM:617081; AllianceGenome:HGNC:29661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAB1; MPRP1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik
Summary: Enables metalloendopeptidase activity. Involved in several processes, including HRI-mediated signaling; mitochondrial protein processing; and regulation of mitochondrion organization. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney (RPKM 9.7), prostate (RPKM 9.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p32.2-p32.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (58480719..58546726, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (58358657..58424702, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (58946391..59012398, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial metallopeptidase OMA1 in cancer.
Title: Mitochondrial metallopeptidase OMA1 in cancer.
Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
Title: Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape.
Title: OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape.
OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization.
Title: OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization.
The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage.
Title: The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage.
Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
Title: Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Title: The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR1276/SIRT4 axis.
Title: Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis.
Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.
Title: Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Title: Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80515 (e-PCR)
- UniSTS:86854

SHGC-148610 (e-PCR)
- UniSTS:176497

D11S3114 (e-PCR)
- UniSTS:152207

AL009888 (e-PCR)
- UniSTS:28589

D1S3381 (e-PCR)
- UniSTS:56250

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in HRI-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cristae formation	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrated stress response signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respiratory chain complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cristae formation	IDA Inferred from Direct Assay more info	PubMed
involved_in zymogen activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed

General protein information

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Preferred Names: metalloendopeptidase OMA1, mitochondrial

Names: OMA1 homolog, zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; metalloprotease-related protein 1; overlapping activity with M-AAA protease; overlapping with the m-AAA protease 1 homolog; zinc metallopeptidase OMA1

NP_660286.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.