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    Zfp112 zinc finger protein 112 [ Mus musculus (house mouse) ]

    Gene ID: 57745, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zfp112provided by MGI
    Official Full Name
    zinc finger protein 112provided by MGI
    Primary source
    MGI:MGI:1929115
    See related
    Ensembl:ENSMUSG00000052675 AllianceGenome:MGI:1929115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf112; Znf228
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; central nervous system; and ureter. Orthologous to human ZNF112 (zinc finger protein 112). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in cortex adult (RPKM 1.6), frontal lobe adult (RPKM 1.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp112 in Genome Data Viewer
    Location:
    7 A3; 7 10.27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23811348..23827254)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24112320..24127952)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36694 Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 180 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 112
    Names
    zfp-112
    zinc finger protein 112 homolog
    zinc finger protein 112; zinc finger protein ZFP112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420121.1 → NP_001407050.1  zinc finger protein 112 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138791
      UniProtKB/TrEMBL
      A0A1L1SUE1
      Related
      ENSMUSP00000150734.2, ENSMUST00000215113.2

    2. NM_001420122.1 → NP_001407051.1  zinc finger protein 112 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138791
      Related
      ENSMUSP00000113031.2, ENSMUST00000120006.8

    3. NM_001420123.1 → NP_001407052.1  zinc finger protein 112 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138791

    4. NM_001420124.1 → NP_001407053.1  zinc finger protein 112 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138791

    5. NM_001420125.1 → NP_001407054.1  zinc finger protein 112 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138791

    6. NM_021307.3 → NP_067282.2  zinc finger protein 112 isoform 1

      See identical proteins and their annotated locations for NP_067282.2

      Status: VALIDATED

      Source sequence(s)
      AC138791
      Consensus CDS
      CCDS39824.1
      UniProtKB/Swiss-Prot
      D3Z7D1, E9QP25, Q0VAW7, Q9R163
      Related
      ENSMUSP00000005413.4, ENSMUST00000005413.4
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:258 → 712
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553 → 573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:621 → 645
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      23811348..23827254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153283.1 → XP_036009176.1  zinc finger protein 112 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:251 → 716
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557 → 577
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VAW7.2 GenPept UniProtKB/Swiss-Prot:Q0VAW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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