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    Gbp7 guanylate binding protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 229900, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gbp7provided by MGI
    Official Full Name
    guanylate binding protein 7provided by MGI
    Primary source
    MGI:MGI:2444421
    See related
    Ensembl:ENSMUSG00000040253 AllianceGenome:MGI:2444421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GBP-7; 9830147J24Rik
    Summary
    Enables GTP binding activity and GTPase activity. Involved in several processes, including cellular response to interferon-beta; cytolysis in another organism; and defense response to other organism. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in thymus primordium. Orthologous to human GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 4.7), liver E18 (RPKM 2.7) and 23 other tissues See more
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    Genomic context

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    See Gbp7 in Genome Data Viewer
    Location:
    3 H1; 3 66.69 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142236097..142255912)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142530336..142550151)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:142138865-142139166 Neighboring gene predicted gene, 54184 Neighboring gene STARR-positive B cell enhancer ABC_E3477 Neighboring gene STARR-positive B cell enhancer ABC_E4602 Neighboring gene guanylate binding protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene guanylate binding protein 3 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene guanylate binding protein 2b Neighboring gene predicted gene, 54185

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail. Legewie L, et al. Biochem J, 2019 Nov 15. PMID 31689351
    2. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways. Feng M, et al. J Virol, 2021 Feb 24. PMID 33408175, Free PMC Article
    3. Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection. Steffens N, et al. mBio, 2020 Jan 21. PMID 31964735, Free PMC Article
    4. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Meunier E, et al. Nature, 2014 May 15. PMID 24739961
    5. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling. Feng S, et al. Nat Commun, 2022 Jul 29. PMID 35906252, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-kappaB and JAK-STAT Signaling Pathways.
      Title: Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways.
    2. GBP7 exhibits a concentration-dependent GTPase activity and an apparent GTP turnover number of 20 min-1.
      Title: Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail.
    3. findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals
      Title: A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytolysis in another organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of type III interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type III interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate-binding protein 7
    Names
    GTP-binding protein 7
    guanine nucleotide-binding protein 7
    guanylate-binding protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083312.2 → NP_001076781.1  guanylate-binding protein 7

      See identical proteins and their annotated locations for NP_001076781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC102108, AK087751
      Consensus CDS
      CCDS38657.1
      UniProtKB/Swiss-Prot
      Q6KAN1, Q78UK8, Q8BU48, Q91Z40
      Related
      ENSMUSP00000132970.2, ENSMUST00000171263.8
      Conserved Domains (3) summary
      pfam02841
      Location:283 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:18 → 281
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:289 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_145545.4 → NP_663520.2  guanylate-binding protein 7

      See identical proteins and their annotated locations for NP_663520.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC102108, AK036666
      Consensus CDS
      CCDS38657.1
      UniProtKB/Swiss-Prot
      Q6KAN1, Q78UK8, Q8BU48, Q91Z40
      Related
      ENSMUSP00000049104.10, ENSMUST00000045097.11
      Conserved Domains (3) summary
      pfam02841
      Location:283 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:18 → 281
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:289 → 579
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      142236097..142255912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Z40.2 GenPept UniProtKB/Swiss-Prot:Q91Z40

    Gene LinkOut

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