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    Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 74340, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ahcyl2provided by MGI
    Official Full Name
    S-adenosylhomocysteine hydrolase-like 2provided by MGI
    Primary source
    MGI:MGI:1921590
    See related
    Ensembl:ENSMUSG00000029772 AllianceGenome:MGI:1921590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0828; Adohcyase3; 4631427C17Rik
    Summary
    Predicted to enable adenosylhomocysteinase activity. Predicted to be involved in S-adenosylmethionine cycle. Located in cytosol; intracellular membrane-bounded organelle; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; nose; respiratory system; and urinary system. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 28.3), kidney adult (RPKM 23.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ahcyl2 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29768378..29912309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29768379..29912310)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 33 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478 Neighboring gene STARR-positive B cell enhancer ABC_E4816 Neighboring gene striatin interacting protein 2 Neighboring gene predicted gene, 52897 Neighboring gene phosphoglycerate kinase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins. Kawaai K, et al. Proc Natl Acad Sci U S A, 2017 Apr 11. PMID 28348216, Free PMC Article
    2. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. Ando H, et al. J Neurochem, 2009 Apr. PMID 19220705
    3. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Vanderweyde T, et al. Cell Rep, 2016 May 17. PMID 27160897, Free PMC Article
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0828

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylhomocysteinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative adenosylhomocysteinase 3
    Names
    S-adenosyl-L-homocysteine hydrolase 3
    S-adenosylhomocysteine hydrolase-like protein 2
    adenosylhomocysteinase 3
    clone MNCb-5555
    long-IRBIT
    NP_001164471.2
    NP_001164472.1
    NP_001334013.1
    NP_067389.5
    XP_006505242.2
    XP_006505243.2
    XP_006505244.1
    XP_006505245.1
    XP_006505246.1
    XP_011239384.1
    XP_030111502.1
    XP_030111503.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171000.2 → NP_001164471.2  putative adenosylhomocysteinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC059255, BC079660, BY733512, CA751283
      Consensus CDS
      CCDS57416.1
      UniProtKB/TrEMBL
      F8WGT1
      Related
      ENSMUSP00000100060.3, ENSMUST00000102995.9
      Conserved Domains (1) summary
      pfam05221
      Location:186 → 611
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    2. NM_001171001.1 → NP_001164472.1  putative adenosylhomocysteinase 3 isoform 3

      See identical proteins and their annotated locations for NP_001164472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK053527, BC059255, BC079660, CF745122
      Consensus CDS
      CCDS51738.1
      UniProtKB/TrEMBL
      Q80TQ9
      Related
      ENSMUSP00000110893.4, ENSMUST00000115238.10
      Conserved Domains (1) summary
      smart00996
      Location:84 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    3. NM_001347084.1 → NP_001334013.1  putative adenosylhomocysteinase 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate exons in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC079216
      Consensus CDS
      CCDS85024.1
      UniProtKB/TrEMBL
      F8WI65, Q80TQ9
      Related
      ENSMUSP00000067638.7, ENSMUST00000064872.13
      Conserved Domains (1) summary
      smart00996
      Location:84 → 507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    4. NM_021414.6 → NP_067389.5  putative adenosylhomocysteinase 3 isoform 1

      See identical proteins and their annotated locations for NP_067389.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC059255, BC079660, BY733512
      Consensus CDS
      CCDS19966.3
      UniProtKB/Swiss-Prot
      Q68FL4, Q8BIH1
      Related
      ENSMUSP00000110897.3, ENSMUST00000115242.9
      Conserved Domains (1) summary
      pfam05221
      Location:187 → 612
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29768378..29912309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241082.3 → XP_011239384.1  putative adenosylhomocysteinase 3 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:226 → 529
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_030255642.1 → XP_030111502.1  putative adenosylhomocysteinase 3 isoform X7

      UniProtKB/TrEMBL
      H3BKT5, Q80TQ9
      Related
      ENSMUSP00000135518.2, ENSMUST00000125911.9
      Conserved Domains (1) summary
      smart00996
      Location:1 → 403
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    3. XM_030255643.2 → XP_030111503.1  putative adenosylhomocysteinase 3 isoform X7

      UniProtKB/TrEMBL
      H3BKT5, Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:1 → 403
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    4. XM_006505182.4 → XP_006505245.1  putative adenosylhomocysteinase 3 isoform X5

      See identical proteins and their annotated locations for XP_006505245.1

      UniProtKB/TrEMBL
      Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:85 → 508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    5. XM_006505181.4 → XP_006505244.1  putative adenosylhomocysteinase 3 isoform X4

      UniProtKB/TrEMBL
      Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:102 → 525
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    6. XM_006505183.4 → XP_006505246.1  putative adenosylhomocysteinase 3 isoform X6

      See identical proteins and their annotated locations for XP_006505246.1

      UniProtKB/TrEMBL
      Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:85 → 508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    7. XM_006505179.2 → XP_006505242.2  putative adenosylhomocysteinase 3 isoform X1

      UniProtKB/TrEMBL
      Q80TQ9
      Conserved Domains (1) summary
      smart00996
      Location:82 → 505
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    8. XM_006505180.2 → XP_006505243.2  putative adenosylhomocysteinase 3 isoform X2

      UniProtKB/TrEMBL
      Q80TQ9
      Related
      ENSMUST00000149816.8
      Conserved Domains (1) summary
      smart00996
      Location:81 → 504
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FL4.1 GenPept UniProtKB/Swiss-Prot:Q68FL4

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