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    Map9 microtubule-associated protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 213582, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Map9provided by MGI
    Official Full Name
    microtubule-associated protein 9provided by MGI
    Primary source
    MGI:MGI:2442208
    See related
    Ensembl:ENSMUSG00000033900 AllianceGenome:MGI:2442208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASAP; Mtap9; 5033421J10Rik; 5330427D05Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within mitotic spindle assembly. Located in astral microtubule and mitotic spindle midzone. Orthologous to human MAP9 (microtubule associated protein 9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in CNS E18 (RPKM 17.3), cortex adult (RPKM 9.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map9 in Genome Data Viewer
    Location:
    3 E3; 3 36.37 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82265379..82302575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (82358072..82395268)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29921 Neighboring gene STARR-seq mESC enhancer starr_08033 Neighboring gene predicted gene, 57713 Neighboring gene STARR-seq mESC enhancer starr_08035 Neighboring gene STARR-positive B cell enhancer mm9_chr3:82161796-82162097 Neighboring gene STARR-seq mESC enhancer starr_08038 Neighboring gene neuropeptide Y receptor Y2 Neighboring gene predicted gene, 29999

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9). Venoux M, et al. BMC Genomics, 2008 Sep 9. PMID 18782428, Free PMC Article
    2. MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer. Wang S, et al. Clin Cancer Res, 2020 Feb 1. PMID 31662330
    3. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
      Title: MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic centrosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in aster IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in astral microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein 9
    Names
    aster-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081230.1 → NP_001074699.1  microtubule-associated protein 9

      See identical proteins and their annotated locations for NP_001074699.1

      Status: VALIDATED

      Source sequence(s)
      AC126248, AC126557
      Consensus CDS
      CCDS38461.1
      UniProtKB/Swiss-Prot
      Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
      UniProtKB/TrEMBL
      A0A0A6YXJ3
      Related
      ENSMUSP00000088535.5, ENSMUST00000091014.10
      Conserved Domains (1) summary
      PTZ00121
      Location:445 → 622
      PTZ00121; MAEBL; Provisional

    2. NM_001356457.1 → NP_001343386.1  microtubule-associated protein 9

      Status: VALIDATED

      Source sequence(s)
      AC126248, AC126557, AK147287
      Consensus CDS
      CCDS38461.1
      UniProtKB/Swiss-Prot
      Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
      UniProtKB/TrEMBL
      A0A0A6YXJ3
      Related
      ENSMUSP00000142206.2, ENSMUST00000195640.2
      Conserved Domains (1) summary
      PTZ00121
      Location:445 → 622
      PTZ00121; MAEBL; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      82265379..82302575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252539.2 → XP_030108399.1  microtubule-associated protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
      UniProtKB/TrEMBL
      A0A0A6YXJ3
      Conserved Domains (1) summary
      PTZ00121
      Location:445 → 622
      PTZ00121; MAEBL; Provisional

    2. XM_030252540.2 → XP_030108400.1  microtubule-associated protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
      UniProtKB/TrEMBL
      A0A0A6YXJ3
      Conserved Domains (1) summary
      PTZ00121
      Location:445 → 622
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TRR0.2 GenPept UniProtKB/Swiss-Prot:Q3TRR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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