Nsd2 nuclear receptor binding SET domain protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nsd2provided by MGI
Official Full Name: nuclear receptor binding SET domain protein 2provided by MGI
Primary source: MGI:MGI:1276574
See related: Ensembl:ENSMUSG00000057406 AllianceGenome:MGI:1276574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MMSET; Whsc1; Whsc1l; mKIAA1090; 5830445G22Rik; 9430010A17Rik; C130020C13Rik; D030027O06Rik; D930023B08Rik
Summary: Enables chromatin binding activity; histone H3K36 trimethyltransferase activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including bone development; cardiac septum morphogenesis; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in CNS E11.5 (RPKM 14.4), CNS E14 (RPKM 12.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.83 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33974286..34055310)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33820676..33897966)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
Title: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.
Title: Multilevel Regulation of NF-κB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.
ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Title: ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development.
Title: Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development.
Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway.
Title: Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway.
NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.
Title: NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.
Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T-cell recruitment.
Title: Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T-cell recruitment.
METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy.
Title: METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy.
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Title: Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
PP2Cdelta Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Title: PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Jcs45 (e-PCR), detects polymorphism
- UniSTS:478881

AW555663 (e-PCR)
- UniSTS:179154

BF388542 (e-PCR)
- UniSTS:244981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 dimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K36 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 trimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrial septum primum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrial septum secundum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membranous septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone-lysine N-methyltransferase NSD2

Names: IL5 promoter REII region-binding protein; multiple myeloma SET domain-containing protein; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; wolf-Hirschhorn syndrome candidate 1 protein homolog

NP_001074571.2

EC 2.1.1.357

NP_001171355.1

EC 2.1.1.357

NP_780440.2

EC 2.1.1.357

XP_006503721.1

EC 2.1.1.357

XP_006503722.1

EC 2.1.1.357

XP_006503723.1

EC 2.1.1.357

XP_006503724.1

EC 2.1.1.357

XP_006503725.1

EC 2.1.1.357

XP_030109896.1

EC 2.1.1.357

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081102.2 → NP_001074571.2 histone-lysine N-methyltransferase NSD2 isoform 1

See identical proteins and their annotated locations for NP_001074571.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). The 5' UTR of this variant may be incomplete due to the lack of 5'-complete transcripts supporting it, and the presence of alternative splicing choices further upstream.

Source sequence(s)

AC163329, BE986660, CF532498, CF742194

Consensus CDS

CCDS51467.1

UniProtKB/Swiss-Prot

Q8BVE8

Related

ENSMUSP00000067205.8, ENSMUST00000066854.14

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:879 → 972

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1013 → 1063

AWS; associated with SET domains

COG5034
Location:546 → 711

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:670 → 712

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:717 → 763

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:764 → 817

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1242 → 1284

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1283 → 1328

C5HCH; NSD Cys-His rich domain

cd19211
Location:1063 → 1204

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:834 → 874

PHD_SF; PHD finger superfamily
NM_001177884.1 → NP_001171355.1 histone-lysine N-methyltransferase NSD2 isoform 3

See identical proteins and their annotated locations for NP_001171355.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (3) with a distinct and significantly shorter C-terminus, compared to isoform 1. The 5' UTR of this variant may be incomplete due to the lack of 5'-complete transcripts supporting it, and the presence of alternative splicing choices further upstream.

Source sequence(s)

AC163329, AK079112, AW494481, CF532498, CF742194

UniProtKB/TrEMBL

B2RY48

Related

ENSMUSP00000117233.2, ENSMUST00000141416.5

Conserved Domains (2) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cl00082
Location:460 → 502

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_175231.2 → NP_780440.2 histone-lysine N-methyltransferase NSD2 isoform 2

See identical proteins and their annotated locations for NP_780440.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. The 5' UTR of this variant may be incomplete due to the lack of 5'-complete transcripts supporting it, and the presence of alternative splicing choices further upstream.

Source sequence(s)

AC163329, BE986660, CF532498, CF742194

Consensus CDS

CCDS51468.1

UniProtKB/Swiss-Prot

B3VCH6, Q6ZPY1, Q7TSF5, Q811F0, Q8BVE8

Related

ENSMUSP00000058940.8, ENSMUST00000058096.14

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:878 → 971

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1012 → 1062

AWS; associated with SET domains

COG5034
Location:546 → 710

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:669 → 711

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:716 → 762

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:763 → 816

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1241 → 1283

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1282 → 1327

C5HCH; NSD Cys-His rich domain

cd19211
Location:1062 → 1203

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:833 → 873

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

33974286..34055310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503658.5 → XP_006503721.1 histone-lysine N-methyltransferase NSD2 isoform X1

See identical proteins and their annotated locations for XP_006503721.1

UniProtKB/Swiss-Prot

Q8BVE8

Related

ENSMUSP00000075210.5, ENSMUST00000075812.11

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:879 → 972

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1013 → 1063

AWS; associated with SET domains

COG5034
Location:546 → 711

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:670 → 712

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:717 → 763

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:764 → 817

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1242 → 1284

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1283 → 1328

C5HCH; NSD Cys-His rich domain

cd19211
Location:1063 → 1204

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:834 → 874

PHD_SF; PHD finger superfamily
XM_006503660.5 → XP_006503723.1 histone-lysine N-methyltransferase NSD2 isoform X2

See identical proteins and their annotated locations for XP_006503723.1

UniProtKB/Swiss-Prot

B3VCH6, Q6ZPY1, Q7TSF5, Q811F0, Q8BVE8

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:878 → 971

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1012 → 1062

AWS; associated with SET domains

COG5034
Location:546 → 710

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:669 → 711

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:716 → 762

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:763 → 816

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1241 → 1283

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1282 → 1327

C5HCH; NSD Cys-His rich domain

cd19211
Location:1062 → 1203

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:833 → 873

PHD_SF; PHD finger superfamily
XM_006503661.5 → XP_006503724.1 histone-lysine N-methyltransferase NSD2 isoform X3

See identical proteins and their annotated locations for XP_006503724.1

UniProtKB/TrEMBL

B2RY48

Conserved Domains (2) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cl00082
Location:460 → 502

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_006503662.5 → XP_006503725.1 histone-lysine N-methyltransferase NSD2 isoform X4

UniProtKB/TrEMBL

D3Z3E0, D3Z3E4

Related

ENSMUSP00000110041.2, ENSMUST00000114399.8

Conserved Domains (2) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cl00082
Location:460 → 502

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_006503659.5 → XP_006503722.1 histone-lysine N-methyltransferase NSD2 isoform X1

See identical proteins and their annotated locations for XP_006503722.1

UniProtKB/Swiss-Prot

Q8BVE8

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:879 → 972

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1013 → 1063

AWS; associated with SET domains

COG5034
Location:546 → 711

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:670 → 712

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:717 → 763

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:764 → 817

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1242 → 1284

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1283 → 1328

C5HCH; NSD Cys-His rich domain

cd19211
Location:1063 → 1204

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:834 → 874

PHD_SF; PHD finger superfamily
XM_030254036.2 → XP_030109896.1 histone-lysine N-methyltransferase NSD2 isoform X2

UniProtKB/Swiss-Prot

B3VCH6, Q6ZPY1, Q7TSF5, Q811F0, Q8BVE8

Conserved Domains (12) summary

cd05837
Location:218 → 337

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:878 → 971

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1012 → 1062

AWS; associated with SET domains

COG5034
Location:546 → 710

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00084
Location:460 → 505

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd15648
Location:669 → 711

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15651
Location:716 → 762

PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)

cd15654
Location:763 → 816

PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)

cd15660
Location:1241 → 1283

PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

pfam17982
Location:1282 → 1327

C5HCH; NSD Cys-His rich domain

cd19211
Location:1062 → 1203

SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins

cl22851
Location:833 → 873

PHD_SF; PHD finger superfamily