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    GAREM2 GRB2 associated regulator of MAPK1 subtype 2 [ Homo sapiens (human) ]

    Gene ID: 150946, updated on 17-Sep-2024

    Summary

    Official Symbol
    GAREM2provided by HGNC
    Official Full Name
    GRB2 associated regulator of MAPK1 subtype 2provided by HGNC
    Primary source
    HGNC:HGNC:27172
    See related
    Ensembl:ENSG00000157833 MIM:617999; AllianceGenome:HGNC:27172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM59B; GAREML
    Expression
    Broad expression in brain (RPKM 5.7), testis (RPKM 1.0) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GAREM2 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26173088..26204304)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26208391..26239634)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26395957..26412532)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SMARCE1 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387200-26387378 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387836-26388007 Neighboring gene peptidylprolyl isomerase like 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26398419-26398957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26401279-26402194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26402195-26403110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11270 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26465316-26465856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26467342-26468022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26468835-26469562 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene adhesion G protein-coupled receptor F3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    GRB2-associated and regulator of MAPK protein 2
    Names
    GRB2 associated regulator of MAPK1 2
    GRB2 associated, regulator of MAPK1-like
    GRB2-associated and regulator of MAPK protein-like
    GRB2-associated and regulator of MAPK1-like
    family with sequence similarity 59, member B
    protein FAM59B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168241.2NP_001161713.1  GRB2-associated and regulator of MAPK protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001161713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AA736392, AB124552, AC011742, CX759737
      Consensus CDS
      CCDS54336.1
      UniProtKB/Swiss-Prot
      B5MC97, B7WNK9, Q75VX8, Q8NF27, Q9UIK8
      Related
      ENSP00000384593.1, ENST00000401533.7
      Conserved Domains (2) summary
      cd09525
      Location:806872
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:29341
      CABIT; Cell-cycle sustaining, positive selection,
    2. NM_001191033.2NP_001177962.1  GRB2-associated and regulator of MAPK protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA736392, AB015349, AC011742, AK090454
      Consensus CDS
      CCDS54337.1
      UniProtKB/Swiss-Prot
      Q75VX8
      Related
      ENSP00000384581.1, ENST00000407684.1
      Conserved Domains (2) summary
      cd09525
      Location:596662
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:7264
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      26173088..26204304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532567.4XP_011530869.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

      Conserved Domains (1) summary
      pfam12736
      Location:29341
      CABIT; Cell-cycle sustaining, positive selection,
    2. XM_006711951.5XP_006712014.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q75VX8
      Conserved Domains (2) summary
      cd09525
      Location:673739
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:29341
      CABIT; Cell-cycle sustaining, positive selection,
    3. XM_011532565.4XP_011530867.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011530867.1

      Conserved Domains (2) summary
      cd09525
      Location:804870
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:36339
      CABIT; Cell-cycle sustaining, positive selection,
    4. XM_011532564.3XP_011530866.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011530866.1

      Conserved Domains (2) summary
      cd09525
      Location:804870
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:36339
      CABIT; Cell-cycle sustaining, positive selection,
    5. XM_011532566.3XP_011530868.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

      Conserved Domains (2) summary
      cd09525
      Location:687753
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:1222
      CABIT; Cell-cycle sustaining, positive selection,

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      26208391..26239634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340696.1XP_054196671.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

    2. XM_054340695.1XP_054196670.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

    3. XM_054340693.1XP_054196668.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    4. XM_054340692.1XP_054196667.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    5. XM_054340694.1XP_054196669.1  GRB2-associated and regulator of MAPK protein 2 isoform X2