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    PLAAT3 phospholipase A and acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 11145, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PLAAT3provided by HGNC
    Official Full Name
    phospholipase A and acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:17825
    See related
    Ensembl:ENSG00000176485 MIM:613867; AllianceGenome:HGNC:17825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AdPLA; FPLD9; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1
    Summary
    Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAAT3 in Genome Data Viewer
    Location:
    11q12.3-q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63574462..63616927, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63563752..63606267, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63341934..63381909, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4871 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3435 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene phospholipase A and acyltransferase 2 Neighboring gene uncharacterized LOC105369335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63368875-63369376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63372619-63373384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63378198-63378707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63379461-63379961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3437 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. Pang XY, et al. J Biol Chem, 2012 Oct 12. PMID 22923616, Free PMC Article
    2. The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. Sers C, et al. Oncogene, 2002 Apr 25. PMID 11973642
    3. Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection. Jarrard WE, et al. PLoS One, 2019. PMID 31233548, Free PMC Article
    4. Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population. Xie XN, et al. Funct Integr Genomics, 2019 Mar. PMID 30343388
    5. H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling. Nazarenko I, et al. Am J Pathol, 2006 Oct. PMID 17003497, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
      Title: PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
    2. Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
      Title: Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
    3. PLA2G16 methylation defines an extensive field defect in histologically normal prostate tissue associated with PC.
      Title: Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection.
    4. PLA2G16 SNPs are associated with the colorectal cancer risk in the Chinese population.
      Title: Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population.
    5. study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release
      Title: PLA2G16 represents a switch between entry and clearance of Picornaviridae.
    6. Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis.
      Title: PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway.
    7. our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity.
      Title: H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
    8. Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome.
      Title: PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis.
    9. suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3
      Title: Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
    10. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
      Title: Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lipodystrophy, familial partial, type 9
    MedGen: C5882746 OMIM: 620683 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organelle disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A and acyltransferase 3
    Names
    Ca-independent phospholipase A1/2
    H-rev 107 protein homolog
    HRAS-like suppressor 1
    HRAS-like suppressor 3
    adipose-specific PLA2
    adipose-specific phospholipase A2
    group XVI phospholipase A1/A2
    group XVI phospholipase A2
    phospholipase A/acyltransferase-3
    phospholipase A2 group XVI
    renal carcinoma antigen NY-REN-65
    NP_001121675.1
    NP_009000.2
    XP_011543043.1
    XP_054223515.1
    XP_054223516.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128203.2 → NP_001121675.1  phospholipase A and acyltransferase 3

      See identical proteins and their annotated locations for NP_001121675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI374456, AI590735, BG719903, CK003948
      Consensus CDS
      CCDS8047.1
      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
      Related
      ENSP00000389124.1, ENST00000415826.3
      Conserved Domains (1) summary
      pfam04970
      Location:19 → 125
      LRAT; Lecithin retinol acyltransferase

    2. NM_007069.3 → NP_009000.2  phospholipase A and acyltransferase 3

      See identical proteins and their annotated locations for NP_009000.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI374456, AI590735, AK313075, AU099540
      Consensus CDS
      CCDS8047.1
      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
      Related
      ENSP00000320337.5, ENST00000323646.9
      Conserved Domains (1) summary
      pfam04970
      Location:19 → 125
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63574462..63616927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544741.2 → XP_011543043.1  phospholipase A and acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011543043.1

      Conserved Domains (1) summary
      pfam04970
      Location:35 → 140
      LRAT; Lecithin retinol acyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63563752..63606267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367540.1 → XP_054223515.1  phospholipase A and acyltransferase 3 isoform X1

    2. XM_054367541.1 → XP_054223516.1  phospholipase A and acyltransferase 3 isoform X2

      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53816.2 GenPept UniProtKB/Swiss-Prot:P53816

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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