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    TSPYL2 TSPY like 2 [ Homo sapiens (human) ]

    Gene ID: 64061, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TSPYL2provided by HGNC
    Official Full Name
    TSPY like 2provided by HGNC
    Primary source
    HGNC:HGNC:24358
    See related
    Ensembl:ENSG00000184205 MIM:300564; AllianceGenome:HGNC:24358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
    Summary
    This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TSPYL2 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53082367..53088540)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52368603..52374776)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53111549..53117722)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene G protein-coupled receptor 173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53122416-53123240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20855 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene Neighboring gene actin gamma 1 pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. Kandalaft LE, et al. Carcinogenesis, 2008 Jun. PMID 18381359, Free PMC Article
    2. Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells. Cardano M, et al. Cell Death Dis, 2023 Mar 15. PMID 36918555, Free PMC Article
    3. hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex. Qu L, et al. J Mol Cell Biol, 2015 Dec. PMID 26089539
    4. hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling. Xie H, et al. Mol Med Rep, 2021 Feb. PMID 33300073, Free PMC Article
    5. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. Ozbun LL, et al. Genomics, 2001 Apr 15. PMID 11318608

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSPYL1 as a Critical Regulator of TGFbeta Signaling through Repression of TGFBR1 and TSPYL2.
      Title: TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2.
    2. CRL2[APPBP2]-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.
      Title: CRL2(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.
    3. A tumor-suppressing role of TSPYL2 in thyroid cancer: Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
      Title: A tumor-suppressing role of TSPYL2 in thyroid cancer: Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
    4. Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.
      Title: Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.
    5. TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation.
      Title: TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation.
    6. hCINAP serves a critical role in hypoxiainduced cardiomyocyte apoptosis via modulating lactate production and mitochondrialmediated apoptosis signaling.
      Title: hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling.
    7. Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SIRT1 and p300 function. We demonstrate that, upon DNA damage, TSPYL2 inhibits SIRT1, disrupting its association with target proteins, and promotes p300 acetylation and activation, finally stimulating p53 acetylation and p53-dependent cell death.
      Title: TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage.
    8. Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy.
      Title: The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
    9. Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms.
      Title: Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1).
    10. TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
      Title: The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rDNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-specific Y-encoded-like protein 2
    Names
    CASK-interacting nucleosome assembly protein
    CTCL tumor antigen se20-4
    CTCL-associated antigen se20-4
    TSPY-like protein 2
    cell division autoantigen 1
    cutaneous T-cell lymphoma-associated antigen se20-4
    cutaneous T-cell lymphoma-associated tumor antigen se20-4
    differentially expressed nucleolar TGF-beta1 target
    differentially-expressed nucleolar TGF-beta1 target protein
    nuclear protein of 79 kDa
    testis-specific protein Y encoded-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013267.1 RefSeqGene

      Range
      5008..11181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022117.4 → NP_071400.1  testis-specific Y-encoded-like protein 2

      See identical proteins and their annotated locations for NP_071400.1

      Status: REVIEWED

      Source sequence(s)
      BC024270, DA076199
      Consensus CDS
      CCDS14350.1
      UniProtKB/Swiss-Prot
      O94799, Q96DG7, Q9BZW6, Q9H2G4
      UniProtKB/TrEMBL
      A8K8U7
      Related
      ENSP00000364591.4, ENST00000375442.8
      Conserved Domains (2) summary
      pfam06957
      Location:543 → 604
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      cl08298
      Location:227 → 396
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      53082367..53088540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029727.2 → XP_016885216.1  testis-specific Y-encoded-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K8U7

    2. XM_017029726.2 → XP_016885215.1  testis-specific Y-encoded-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K8U7
      Conserved Domains (2) summary
      NF000535
      Location:486 → 660
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl08298
      Location:227 → 440
      NAP; Nucleosome assembly protein (NAP)

    3. XM_006724592.5 → XP_006724655.1  testis-specific Y-encoded-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K8U7
      Conserved Domains (2) summary
      pfam06957
      Location:543 → 604
      COPI_C; Coatomer (COPI) alpha subunit C-terminus
      cl08298
      Location:227 → 396
      NAP; Nucleosome assembly protein (NAP)

    4. XM_047442353.1 → XP_047298309.1  testis-specific Y-encoded-like protein 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52368603..52374776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327567.1 → XP_054183542.1  testis-specific Y-encoded-like protein 2 isoform X2

    2. XM_054327566.1 → XP_054183541.1  testis-specific Y-encoded-like protein 2 isoform X1

    3. XM_054327568.1 → XP_054183543.1  testis-specific Y-encoded-like protein 2 isoform X3

    4. XM_054327569.1 → XP_054183544.1  testis-specific Y-encoded-like protein 2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2G4.1 GenPept UniProtKB/Swiss-Prot:Q9H2G4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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