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    SLC37A2 solute carrier family 37 member 2 [ Homo sapiens (human) ]

    Gene ID: 219855, updated on 17-Jun-2024

    Summary

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    Official Symbol
    SLC37A2provided by HGNC
    Official Full Name
    solute carrier family 37 member 2provided by HGNC
    Primary source
    HGNC:HGNC:20644
    See related
    Ensembl:ENSG00000134955 MIM:619136; AllianceGenome:HGNC:20644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPX2; pp11662
    Summary
    Enables glucose 6-phosphate:inorganic phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal (RPKM 13.0), salivary gland (RPKM 12.4) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC37A2 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125063305..125090516)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125091969..125119183)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124933201..124960412)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:124823758-124824301 Neighboring gene CCDC15 divergent transcript Neighboring gene coiled-coil domain containing 15 Neighboring gene MPRA-validated peak1499 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124853252-124854004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124951446-124951995 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124952423-124953622 Neighboring gene transmembrane protein 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:124981662-124982574 Neighboring gene keratin 18 pseudogene 59

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human sugar-phosphate/phosphate exchanger family SLC37. Bartoloni L, et al. Pflugers Arch, 2004 Feb. PMID 12811562
    2. Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Villani A, et al. Dev Cell, 2019 Apr 8. PMID 30880002
    3. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00171, MGC71430

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose-6-phosphate transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A2
    Names
    solute carrier family 37 (glucose-6-phosphate transporter), member 2
    solute carrier family 37 (glycerol-3-phosphate transporter), member 2
    sugar phosphate exchanger 2
    sugar-phosphate exchange protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145290.2 → NP_001138762.1  glucose-6-phosphate exchanger SLC37A2 isoform 2

      See identical proteins and their annotated locations for NP_001138762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region that causes a frameshift. The resulting isoform (2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK290314, AP001007
      Consensus CDS
      CCDS44757.1
      UniProtKB/Swiss-Prot
      A8K2P9, Q6P599, Q7Z7P8, Q8TED4, Q8TEM2
      Related
      ENSP00000384407.3, ENST00000403796.7
      Conserved Domains (2) summary
      cd06174
      Location:86 → 481
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:87 → 463
      2A0104; phosphoglycerate transporter family protein

    2. NM_198277.3 → NP_938018.1  glucose-6-phosphate exchanger SLC37A2 isoform 1

      See identical proteins and their annotated locations for NP_938018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK074207, AP001007, BC051314
      Consensus CDS
      CCDS31714.1
      UniProtKB/Swiss-Prot
      Q8TED4
      Related
      ENSP00000311833.4, ENST00000308074.4
      Conserved Domains (1) summary
      cl27298
      Location:25 → 478
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      125063305..125090516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426544.1 → XP_047282500.1  glucose-6-phosphate exchanger SLC37A2 isoform X1

    RNA

    1. XR_007062459.1 RNA Sequence

    2. XR_007062460.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      125091969..125119183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367989.1 → XP_054223964.1  glucose-6-phosphate exchanger SLC37A2 isoform X1

    RNA

    1. XR_008488359.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TED4.2 GenPept UniProtKB/Swiss-Prot:Q8TED4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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