AURKC aurora kinase C [Homo sapiens (human)] - Gene

Summary

Official Symbol: AURKCprovided by HGNC
Official Full Name: aurora kinase Cprovided by HGNC
Primary source: HGNC:HGNC:11391
See related: Ensembl:ENSG00000105146 MIM:603495; AllianceGenome:HGNC:11391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (57231023..57235548)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (60327568..60332080)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (57742391..57746916)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
Title: Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.
Title: Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.
Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.
Title: Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.
The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.
Title: The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.
Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.
Title: Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.
Co-relation with novel phosphorylation sites of IkappaBalpha and necroptosis in breast cancer cells.
Title: Co-relation with novel phosphorylation sites of IκBα and necroptosis in breast cancer cells.
Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia.
Title: Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia.
Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.
Title: Two frequent loss-of-function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia.
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
Title: Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Infertility associated with multi-tailed spermatozoa and excessive DNA MedGen: C0403812 OMIM: 243060 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482311

NoName (e-PCR)
- UniSTS:489738

AURKC (e-PCR)
- UniSTS:279155

STK13 (e-PCR)
- UniSTS:279155

AURKC (e-PCR)
- UniSTS:504452

RH93146 (e-PCR)
- UniSTS:91297

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	TAS Traceable Author Statement more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle midzone assembly	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	TAS Traceable Author Statement more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	TAS Traceable Author Statement more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase C

Names: ARK-3; aurora 3; aurora-related kinase 3; aurora/IPL1-related kinase 3; aurora/IPL1/EG2 protein 2; epididymis secretory protein Li 90; serine/threonine kinase 13 (aurora/IPL1-like); serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C

NP_001015878.1

EC 2.7.11.1

NP_001015879.1

EC 2.7.11.1

NP_003151.2

EC 2.7.11.1

XP_047295209.1

EC 2.7.11.1

XP_054177818.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012134.1 RefSeqGene

Range

5015..9540

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001015878.2 → NP_001015878.1 aurora kinase C isoform 1

See identical proteins and their annotated locations for NP_001015878.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC005261, AF054621, AY661554

Consensus CDS

CCDS33128.1

UniProtKB/Swiss-Prot

O60681, O75442, Q6AZY8, Q6DLZ0, Q9UPK5, Q9UQB9

UniProtKB/TrEMBL

Q5Y191

Related

ENSP00000302898.6, ENST00000302804.12

Conserved Domains (2) summary

smart00220
Location:43 → 293

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14117
Location:36 → 305

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
NM_001015879.2 → NP_001015879.1 aurora kinase C isoform 2

See identical proteins and their annotated locations for NP_001015879.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as Aurora C-SV, uses an alternate splice site at the 5' end of the first intron and an alternate upstream translation initiation site, compared to variant 1. The encoded protein (isoform 2) contains a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB017332, AY661554, BX092186

Consensus CDS

CCDS46205.1

UniProtKB/TrEMBL

V9HW16

Related

ENSP00000407162.1, ENST00000415300.6

Conserved Domains (2) summary

smart00220
Location:24 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14117
Location:17 → 286

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
NM_003160.3 → NP_003151.2 aurora kinase C isoform 3

See identical proteins and their annotated locations for NP_003151.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site at the 5' end of the first intron and an alternate downstream translation initiation site, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB017332, AF054621, AF059681, AY661554

Consensus CDS

CCDS46206.1

UniProtKB/TrEMBL

V9HW16

Related

ENSP00000471830.1, ENST00000598785.5

Conserved Domains (1) summary

cl21453
Location:2 → 271

PKc_like; Protein Kinases, catalytic domain