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    WNT9A Wnt family member 9A [ Homo sapiens (human) ]

    Gene ID: 7483, updated on 2-Nov-2024

    Summary

    Official Symbol
    WNT9Aprovided by HGNC
    Official Full Name
    Wnt family member 9Aprovided by HGNC
    Primary source
    HGNC:HGNC:12778
    See related
    Ensembl:ENSG00000143816 MIM:602863; AllianceGenome:HGNC:12778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WNT14
    Summary
    The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 3.6), endometrium (RPKM 2.9) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WNT9A in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (227918656..227947932, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227107683..227136953, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228106357..228135633, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227980229-227980892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227981557-227982220 Neighboring gene MPRA-validated peak748 silencer Neighboring gene serine protease 38 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228073527-228074122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228074123-228074719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228083643-228084489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228087252-228087752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228088986-228089986 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228101825-228101974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228102681-228103478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228103479-228104275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228107156-228108019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228108020-228108882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228114017-228114769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228117534-228118094 Neighboring gene negCOR silencer S7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228129831-228130733 Neighboring gene uncharacterized LOC124904533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1904 Neighboring gene microRNA 5008 Neighboring gene uncharacterized LOC107985355 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138165, MGC141991

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cornea development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in embryonic skeletal joint development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in iris morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Wnt-9a
    Names
    wingless-type MMTV integration site family, member 14
    wingless-type MMTV integration site family, member 9A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003395.4NP_003386.1  protein Wnt-9a precursor

      See identical proteins and their annotated locations for NP_003386.1

      Status: VALIDATED

      Source sequence(s)
      AB060283, AI280246, AK131041, AL360269
      Consensus CDS
      CCDS31045.1
      UniProtKB/Swiss-Prot
      A6NLW2, O14904, Q2M2J3, Q5VWU0, Q96S50
      UniProtKB/TrEMBL
      D9ZGG3
      Related
      ENSP00000272164.5, ENST00000272164.6
      Conserved Domains (1) summary
      cl38924
      Location:64364
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      227918656..227947932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544271.3XP_011542573.1  protein Wnt-9a isoform X1

      Conserved Domains (1) summary
      pfam00110
      Location:1294
      wnt; wnt family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227107683..227136953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338613.1XP_054194588.1  protein Wnt-9a isoform X1