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    BOC BOC cell adhesion associated, oncogene regulated [ Homo sapiens (human) ]

    Gene ID: 91653, updated on 27-Nov-2024

    Summary

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    Official Symbol
    BOCprovided by HGNC
    Official Full Name
    BOC cell adhesion associated, oncogene regulatedprovided by HGNC
    Primary source
    HGNC:HGNC:17173
    See related
    Ensembl:ENSG00000144857 MIM:608708; AllianceGenome:HGNC:17173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Boi; CDON2
    Summary
    The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in skin (RPKM 11.2), prostate (RPKM 10.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BOC in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113210926..113287459)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115932521..116008527)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112930404..113006306)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NEPRO antisense RNA 1 Neighboring gene uncharacterized LOC124906268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112842917-112843418 Neighboring gene long intergenic non-protein coding RNA 2044 Neighboring gene uncharacterized LOC124909486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112930765-112931416 Neighboring gene uncharacterized LOC124909409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112983897-112984515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112991758-112992620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20249 Neighboring gene SPICE1-CFAP44 readthrough (NMD candidate) Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:113031132-113031687 Neighboring gene cilia and flagella associated protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113085321-113085822 Neighboring gene Sharpr-MPRA regulatory region 3247 Neighboring gene RABGGTB pseudogene 1 Neighboring gene PHF5A pseudogene 2 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20251 Neighboring gene microRNA 8076

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BOC is a modifier gene in holoprosencephaly. Hong M, et al. Hum Mutat, 2017 Nov. PMID 28677295, Free PMC Article
    2. Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis. Dai Z, et al. Spine (Phila Pa 1976), 2021 Nov 15. PMID 33958541
    3. Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics. Ahmed S, et al. Heart Vessels, 2020 Nov. PMID 32651845, Free PMC Article
    4. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. Wegorzewska M, et al. Mol Carcinog, 2003 May. PMID 12720294
    5. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. Onodera S, et al. PLoS One, 2017. PMID 28915250, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.
      Title: Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.
    2. Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics.
      Title: Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics.
    3. we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays.
      Title: BOC is a modifier gene in holoprosencephaly.
    4. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
      Title: A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
    5. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype
      Title: Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype.
    6. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner
      Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
    7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
    8. Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm.
      Title: Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc.
    9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage
      Title: Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD.
    10. Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity.
      Title: The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    brother of CDO
    Names
    Boc homolog
    brother of CDON
    cell adhesion associated, oncogene regulated 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301861.2 → NP_001288790.1  brother of CDO isoform 1 precursor

      See identical proteins and their annotated locations for NP_001288790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA716090, AC026329, AK074556, AY027658, AY358328, BC075829, DA247804, DB349011
      Consensus CDS
      CCDS77788.1
      UniProtKB/Swiss-Prot
      Q9BWV1
      Related
      ENSP00000273395.4, ENST00000273395.8
      Conserved Domains (6) summary
      cd00063
      Location:607 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 560
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    2. NM_001301867.2 → NP_001288796.1  brother of CDO isoform 3 precursor

      See identical proteins and their annotated locations for NP_001288796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC026329, AK056359, BC034614, BC075829, DA721979
      Consensus CDS
      CCDS77789.1
      UniProtKB/TrEMBL
      Q96DN7
      Related
      ENSP00000420154.1, ENST00000485230.5
      Conserved Domains (2) summary
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      cd00096
      Location:53 → 59
      Ig; Ig strand B [structural motif]

    3. NM_001378073.1 → NP_001365002.1  brother of CDO isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS77788.1
      Conserved Domains (6) summary
      cd00063
      Location:607 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 560
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    4. NM_001378074.1 → NP_001365003.1  brother of CDO isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS77788.1
      Related
      ENSP00000507783.1, ENST00000682979.1
      Conserved Domains (6) summary
      cd00063
      Location:607 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 560
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    5. NM_001378075.1 → NP_001365004.1  brother of CDO isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS2971.1
      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    6. NM_001387919.1 → NP_001374848.1  brother of CDO isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS77788.1
      Conserved Domains (6) summary
      cd00063
      Location:607 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 560
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    7. NM_001387920.1 → NP_001374849.1  brother of CDO isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS2971.1
      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    8. NM_001387921.1 → NP_001374850.1  brother of CDO isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS2971.1
      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    9. NM_001387922.1 → NP_001374851.1  brother of CDO isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS77789.1
      UniProtKB/TrEMBL
      Q96DN7
      Conserved Domains (2) summary
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      cd00096
      Location:53 → 59
      Ig; Ig strand B [structural motif]

    10. NM_001387923.1 → NP_001374852.1  brother of CDO isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Consensus CDS
      CCDS77789.1
      UniProtKB/TrEMBL
      Q96DN7
      Conserved Domains (2) summary
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      cd00096
      Location:53 → 59
      Ig; Ig strand B [structural motif]

    11. NM_001387924.1 → NP_001374853.1  brother of CDO isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (6) summary
      cd00063
      Location:516 → 607
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:395 → 469
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:321 → 382
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    12. NM_001387925.1 → NP_001374854.1  brother of CDO isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    13. NM_001387926.1 → NP_001374855.1  brother of CDO isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (6) summary
      cd00063
      Location:607 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 560
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    14. NM_001387927.1 → NP_001374856.1  brother of CDO isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    15. NM_001387928.1 → NP_001374857.1  brother of CDO isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    16. NM_001387929.1 → NP_001374858.1  brother of CDO isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (4) summary
      pfam13927
      Location:322 → 395
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    17. NM_001387930.1 → NP_001374859.1  brother of CDO isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (4) summary
      pfam13927
      Location:322 → 395
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    18. NM_001387932.1 → NP_001374861.1  brother of CDO isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC026329
      Conserved Domains (3) summary
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      cd00096
      Location:53 → 59
      Ig; Ig strand B [structural motif]
      cl11960
      Location:129 → 204
      Ig; Immunoglobulin domain

    19. NM_033254.4 → NP_150279.1  brother of CDO isoform 2 precursor

      See identical proteins and their annotated locations for NP_150279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AA716090, AK074556, AY027658, AY358328, BC075829, DA721979, DB349011
      Consensus CDS
      CCDS2971.1
      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
      Related
      ENSP00000418663.1, ENST00000495514.5
      Conserved Domains (6) summary
      cd00063
      Location:606 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:486 → 559
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:409 → 473
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    RNA

    1. NR_170866.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC026329

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      113210926..113287459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449188.1 → XP_047305144.1  brother of CDO isoform X11

    2. XM_047449184.1 → XP_047305140.1  brother of CDO isoform X9

    3. XM_047449186.1 → XP_047305142.1  brother of CDO isoform X11

    4. XM_047449187.1 → XP_047305143.1  brother of CDO isoform X11

    5. XM_047449173.1 → XP_047305129.1  brother of CDO isoform X1

    6. XM_017007446.2 → XP_016862935.1  brother of CDO isoform X5

      Conserved Domains (6) summary
      cd00063
      Location:610 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:489 → 563
      fn3; Fibronectin type III domain
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      pfam16625
      Location:414 → 476
      ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
      cd00096
      Location:248 → 252
      Ig; Ig strand B [structural motif]
      cl11960
      Location:239 → 306
      Ig; Immunoglobulin domain

    7. XM_047449177.1 → XP_047305133.1  brother of CDO isoform X2

    8. XM_017007450.3 → XP_016862939.1  brother of CDO isoform X6

    9. XM_047449178.1 → XP_047305134.1  brother of CDO isoform X3

    10. XM_047449181.1 → XP_047305137.1  brother of CDO isoform X7

    11. XM_047449180.1 → XP_047305136.1  brother of CDO isoform X4

    12. XM_047449182.1 → XP_047305138.1  brother of CDO isoform X8

      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
      Related
      ENSP00000347546.3, ENST00000355385.7

    13. XM_047449185.1 → XP_047305141.1  brother of CDO isoform X10

    14. XM_047449189.1 → XP_047305145.1  brother of CDO isoform X12

    15. XM_047449190.1 → XP_047305146.1  brother of CDO isoform X13

    16. XM_047449175.1 → XP_047305131.1  brother of CDO isoform X1

    17. XM_047449183.1 → XP_047305139.1  brother of CDO isoform X8

      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

    18. XM_047449191.1 → XP_047305147.1  brother of CDO isoform X14

    19. XM_047449179.1 → XP_047305135.1  brother of CDO isoform X3

    20. XM_047449192.1 → XP_047305148.1  brother of CDO isoform X15

    21. XM_017007455.2 → XP_016862944.1  brother of CDO isoform X16

      UniProtKB/TrEMBL
      Q96DN7
      Related
      ENSP00000417337.1, ENST00000484034.1
      Conserved Domains (2) summary
      pfam13927
      Location:36 → 109
      Ig_3; Immunoglobulin domain
      cd00096
      Location:53 → 59
      Ig; Ig strand B [structural motif]

    22. XM_047449176.1 → XP_047305132.1  brother of CDO isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      115932521..116008527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348348.1 → XP_054204323.1  brother of CDO isoform X9

    2. XM_054348350.1 → XP_054204325.1  brother of CDO isoform X11

    3. XM_054348351.1 → XP_054204326.1  brother of CDO isoform X11

    4. XM_054348336.1 → XP_054204311.1  brother of CDO isoform X1

    5. XM_054348343.1 → XP_054204318.1  brother of CDO isoform X5

    6. XM_054348339.1 → XP_054204314.1  brother of CDO isoform X2

    7. XM_054348344.1 → XP_054204319.1  brother of CDO isoform X6

    8. XM_054348340.1 → XP_054204315.1  brother of CDO isoform X3

    9. XM_054348345.1 → XP_054204320.1  brother of CDO isoform X7

    10. XM_054348342.1 → XP_054204317.1  brother of CDO isoform X4

    11. XM_054348346.1 → XP_054204321.1  brother of CDO isoform X8

      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

    12. XM_054348349.1 → XP_054204324.1  brother of CDO isoform X10

    13. XM_054348352.1 → XP_054204327.1  brother of CDO isoform X12

    14. XM_054348353.1 → XP_054204328.1  brother of CDO isoform X13

    15. XM_054348337.1 → XP_054204312.1  brother of CDO isoform X1

    16. XM_054348347.1 → XP_054204322.1  brother of CDO isoform X8

      UniProtKB/Swiss-Prot
      A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

    17. XM_054348354.1 → XP_054204329.1  brother of CDO isoform X14

    18. XM_054348341.1 → XP_054204316.1  brother of CDO isoform X3

    19. XM_054348355.1 → XP_054204330.1  brother of CDO isoform X15

    20. XM_054348356.1 → XP_054204331.1  brother of CDO isoform X16

      UniProtKB/TrEMBL
      Q96DN7

    21. XM_054348338.1 → XP_054204313.1  brother of CDO isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWV1.1 GenPept UniProtKB/Swiss-Prot:Q9BWV1

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