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    CASC15 cancer susceptibility 15 [ Homo sapiens (human) ]

    Gene ID: 401237, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CASC15provided by HGNC
    Official Full Name
    cancer susceptibility 15provided by HGNC
    Primary source
    HGNC:HGNC:28245
    See related
    MIM:616610; AllianceGenome:HGNC:28245
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CANT; LINC00340; lnc-SOX4-1
    Summary
    This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]
    Expression
    Broad expression in ovary (RPKM 2.9), endometrium (RPKM 1.9) and 14 other tissues See more
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    Genomic context

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    See CASC15 in Genome Data Viewer
    Location:
    6p22.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (21666413..22195820)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (21539084..22068639)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (21666644..22196049)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24142 Neighboring gene bolA family member 2 pseudogene 3 Neighboring gene MPRA-validated peak5729 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:21649156-21649656 Neighboring gene uncharacterized LOC124901483 Neighboring gene Sharpr-MPRA regulatory region 7931 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:21721085-21721584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:21739035-21739957 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:21740882-21741804 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:21741805-21742728 Neighboring gene uncharacterized LOC124901274 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:21769680-21770293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:21770817-21771316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:21773448-21774170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:21798093-21798690 Neighboring gene uncharacterized LOC105374970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24144 Neighboring gene Sharpr-MPRA regulatory region 6328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16987 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:21873881-21875080 Neighboring gene Sharpr-MPRA regulatory region 8833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:22027355-22028066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24148 Neighboring gene RN7SK pseudogene 240 Neighboring gene NANOG hESC enhancer GRCh37_chr6:22145447-22145948 Neighboring gene VISTA enhancer hs1335 Neighboring gene neuroblastoma associated transcript 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:22198729-22199928 Neighboring gene uncharacterized LOC124901275 Neighboring gene NGRN pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Russell MR, et al. Cancer Res, 2015 Aug 1. PMID 26100672, Free PMC Article
    2. Higher lncRNA CASC15 expression predicts poor prognosis and associates with tumor growth in cervical cancer. Shan S, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720157
    3. CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer. Bai Y, et al. Cell Cycle, 2019 Sep. PMID 31378128, Free PMC Article
    4. LncRNA CACS15 regulates tongue squamous cell carcinoma cell behaviors and predicts survival. Wu X, et al. BMC Oral Health, 2019 Oct 29. PMID 31665008, Free PMC Article
    5. Long Non-Coding RNA-CASC15 Promotes Cell Proliferation, Migration, and Invasion by Activating Wnt/β-Catenin Signaling Pathway in Melanoma. Sheng L, et al. Pathobiology, 2020. PMID 31838468

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression via EMT.
      Title: Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression via EMT.
    2. Prognostic value of CASC15 and LINC01600 as competitive endogenous RNAs in lung adenocarcinoma: An observational study.
      Title: Prognostic value of CASC15 and LINC01600 as competitive endogenous RNAs in lung adenocarcinoma: An observational study.
    3. A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis.
      Title: A study of the prognostic value of long non-coding RNA CASC15 in human solid tumors utilizing The Cancer Genome Atlas (TCGA) datasets and a meta-analysis.
    4. LncRNA-CASC15 knockdown inhibits the progression of esophageal squamous cell carcinoma through targeting miR-33a-5p/PTGS2 axis.
      Title: LncRNA-CASC15 knockdown inhibits the progression of esophageal squamous cell carcinoma through targeting miR-33a-5p/PTGS2 axis.
    5. CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children.
      Title: CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children.
    6. [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].
      Title: [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].
    7. LncRNA CASC15 regulates breast cancer cell stemness via the miR-654-5p/MEF2D axis.
      Title: LncRNA CASC15 regulates breast cancer cell stemness via the miR-654-5p/MEF2D axis.
    8. LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.
      Title: LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.
    9. lncRNACASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelialmesenchymal transition via the Wnt/betacatenin signaling pathway.
      Title: lncRNA‑CASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway.
    10. Long noncoding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTOmediated demethylation.
      Title: Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
    EBI GWAS Catalog
    Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
    EBI GWAS Catalog
    Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
    EBI GWAS Catalog
    Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • cancer susceptibility 15 (non-protein coding)
    • cancer susceptibility candidate 15 (non-protein coding)
    • long intergenic non-protein coding RNA 340

    Clone Names

    • FLJ12803, FLJ17254, FLJ22536, FLJ51318

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015410.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK026189, AL161436, AL359694, HY067675

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      21666413..22195820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      21539084..22068639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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