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    OR51B2 olfactory receptor family 51 subfamily B member 2 [ Homo sapiens (human) ]

    Gene ID: 79345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OR51B2provided by HGNC
    Official Full Name
    olfactory receptor family 51 subfamily B member 2provided by HGNC
    Primary source
    HGNC:HGNC:14703
    See related
    Ensembl:ENSG00000279012 AllianceGenome:HGNC:14703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR51B1P; HOR5'Beta3
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
    all
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    Genomic context

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    See OR51B2 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5323359..5324297, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5382724..5383662, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5344589..5345527, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene beta-globin locus control region Neighboring gene olfactory receptor family 51 subfamily B member 4 Neighboring gene olfactory receptor family 51 subfamily B member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily B member 8 pseudogene Neighboring gene olfactory receptor family 51 subfamily B member 5 Neighboring gene olfactory receptor family 51 subfamily B member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From musk to body odor: Decoding olfaction through genetic variation. Li B, et al. PLoS Genet, 2022 Feb. PMID 35113854, Free PMC Article
    2. Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase. Chen X, et al. Nat Chem Biol, 2021 Mar. PMID 33398168
    3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Bulger M, et al. Proc Natl Acad Sci U S A, 1999 Apr 27. PMID 10220430, Free PMC Article
    4. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Bulger M, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121057, Free PMC Article
    5. A probabilistic classifier for olfactory receptor pseudogenes. Menashe I, et al. BMC Bioinformatics, 2006 Aug 29. PMID 16939646, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. From musk to body odor: Decoding olfaction through genetic variation.
      Title: From musk to body odor: Decoding olfaction through genetic variation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 51B2
    Names
    odorant receptor HOR5'beta3
    olfactory receptor 51B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033180.5 → NP_149420.4  olfactory receptor 51B2

      See identical proteins and their annotated locations for NP_149420.4

      Status: VALIDATED

      Source sequence(s)
      AC104389
      UniProtKB/Swiss-Prot
      Q17R53, Q96RD4, Q9Y5P1
      UniProtKB/TrEMBL
      A0A126GWB2
      Related
      ENSP00000485407.1, ENST00000624187.1
      Conserved Domains (2) summary
      pfam00001
      Location:39 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29 → 306
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5323359..5324297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5382724..5383662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5P1.4 GenPept UniProtKB/Swiss-Prot:Q9Y5P1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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