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    FOLH1B folate hydrolase 1B (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 219595, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FOLH1Bprovided by HGNC
    Official Full Name
    folate hydrolase 1B (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:13636
    See related
    MIM:609020; AllianceGenome:HGNC:13636
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSM; FOLH2; FOLHP; PSMAL; PSMA-LIKE
    Summary
    Enables metallocarboxypeptidase activity. Involved in C-terminal protein deglutamylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum (RPKM 38.8), prostate (RPKM 20.3) and 6 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FOLH1B in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89659268..89698718)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89578945..89618403)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89392436..89431886)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 4 Neighboring gene H3 histone pseudogene 34 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89304186-89305004 Neighboring gene Sharpr-MPRA regulatory region 15382 Neighboring gene uncharacterized LOC124902843 Neighboring gene UBTF like 10 (pseudogene) Neighboring gene tripartite motif containing 77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. O'Keefe DS, et al. Prostate, 2004 Feb 1. PMID 14716746
    2. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. O'Keefe DS, et al. Biochim Biophys Acta, 1998 Nov 26. PMID 9838072
    3. Detailed genetic mapping around a putative prostate-specific membrane antigen locus on human chromosome 11p11.2. Maraj BH, et al. Cytogenet Cell Genet, 1998. PMID 9691167
    4. Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. Lambert LA, et al. J Mol Evol, 2007 Jan. PMID 17160644
    5. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Israeli RS, et al. Cancer Res, 1993 Jan 15. PMID 8417812

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • N-acetylated-alpha-linked-acidic dipeptidase
    • cell growth-inhibiting gene 26 protein
    • folate hydrolase 2
    • prostate-specific membrane antigen-like protein
    • putative N-acetylated-alpha-linked acidic dipeptidase
    • putative folate hydrolase 1B

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_175944.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP003122

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      89659268..89698718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      89578945..89618403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_003258.2: Suppressed sequence

      Description
      NG_003258.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.

    2. NM_001395847.1: Suppressed sequence

      Description
      NM_001395847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    3. NM_153696.3: Suppressed sequence

      Description
      NM_153696.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBA9.1 GenPept UniProtKB/Swiss-Prot:Q9HBA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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