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    IL20RA interleukin 20 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 53832, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL20RAprovided by HGNC
    Official Full Name
    interleukin 20 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:6003
    See related
    Ensembl:ENSG00000016402 MIM:605620; AllianceGenome:HGNC:6003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha
    Summary
    This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in skin (RPKM 13.8), adrenal (RPKM 3.9) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL20RA in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (136999971..137044965, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138187753..138232746, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137321108..137366102, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr6:137298202-137298732 Neighboring gene ribosomal protein L35a pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137311375-137312331 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137322965-137323508 Neighboring gene neuroblastoma highly expressed DDX5 stabilizing lncRNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90349 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17579 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137382319-137382457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25128 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137410449-137410629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25131 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25133 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90359 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90362 Neighboring gene interleukin 22 receptor subunit alpha 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137492881-137493639 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:137500946-137502145 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:137540162-137540892 Neighboring gene interferon gamma receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer. Gao W, et al. Theranostics, 2021. PMID 33456560, Free PMC Article
    2. CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases. Wu J, et al. Genes Immun, 2019 Feb. PMID 29483615
    3. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Wang M, et al. J Biol Chem, 2002 Mar 1. PMID 11706020
    4. Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1. Zahradník J, et al. FEBS J, 2019 Oct. PMID 31152679
    5. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Sheikh F, et al. J Immunol, 2004 Feb 15. PMID 14764663

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.
      Title: MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.
    2. IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.
      Title: IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.
    3. Multiple sequence alignment explains the stabilizing effect of the mutated residues in the IL-24 variants by their presence in the related and more stable cytokines IL-20 and IL-19
      Title: Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1.
    4. IL-20RA gene as a risk factor for multiple autoimmune diseases.
      Title: CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.
    5. the DNA fragment containing the associated SNPs interacts through chromatin looping not only with TNFAIP3, but also with IL20RA, located 680 kb upstream.
      Title: Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.
    6. IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy.
      Title: IL24 and its Receptors Regulate Growth and Migration of Pancreatic Cancer Cells and Are Potential Biomarkers for IL24 Molecular Therapy.
    7. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
      Title: Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. IL-20RA polymorphisms may have a role in psoriasis
      Title: Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.
    10. Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
      Title: Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20 receptor subunit alpha
    Names
    class II cytokine receptor ZCYTOR7
    cytokine receptor family 2 member 8
    interleukin 20 receptor alpha subunit
    interleukin 20 receptor, alpha
    interleukin-20 receptor I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278722.2 → NP_001265651.2  interleukin-20 receptor subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL135902
      Consensus CDS
      CCDS64536.1
      UniProtKB/TrEMBL
      B2RCV2
      Related
      ENSP00000437843.1, ENST00000541547.5
      Conserved Domains (2) summary
      pfam01108
      Location:1 → 74
      Tissue_fac; Tissue factor
      pfam09294
      Location:86 → 190
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    2. NM_001278723.3 → NP_001265652.2  interleukin-20 receptor subunit alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL135902
      Consensus CDS
      CCDS64535.1
      Related
      ENSP00000356722.1, ENST00000367748.4
      Conserved Domains (1) summary
      pfam09294
      Location:25 → 128
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    3. NM_001278724.4 → NP_001265653.2  interleukin-20 receptor subunit alpha isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL135902
      Conserved Domains (1) summary
      pfam09294
      Location:21 → 106
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    4. NM_014432.4 → NP_055247.4  interleukin-20 receptor subunit alpha isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL135902
      Consensus CDS
      CCDS5181.1
      UniProtKB/Swiss-Prot
      B4DLR5, F5H675, Q14CW2, Q6UWA9, Q96SH8, Q9UHF4
      UniProtKB/TrEMBL
      B2RCV2
      Related
      ENSP00000314976.5, ENST00000316649.10
      Conserved Domains (2) summary
      pfam01108
      Location:27 → 123
      Tissue_fac; Tissue factor
      pfam09294
      Location:135 → 239
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      136999971..137044965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010954.3 → XP_016866443.1  interleukin-20 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      B2RCV2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      138187753..138232746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355668.1 → XP_054211643.1  interleukin-20 receptor subunit alpha isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHF4.2 GenPept UniProtKB/Swiss-Prot:Q9UHF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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